Wow, interesting, I didn't expect that. I guess I lumped antivirals together, and knew that hydroxychloroquine and ivermectin were widely used. They must work differently than Mol.
They all have different MoAs. Hydroxychloroquine is assumed to operate mainly by targeting the endosomal route of the virus. It shows tropism form the endosomes, and when lysosomes bind they acidify the environment and that traps chloroquine analogues while also preventing the pH from dropping. This is assumed to help with SARS-COV2, especially the Omicrons since it stops them from being released inside the cell. There are other MoAs outlined in my Anthology Series on Hydroxychloroquine.
I didn't dive into Ivermectin but it's assumed several MoAs may be occurring, but I left that for others since that seemed to be something other people were already covering.
Wow, interesting, I didn't expect that. I guess I lumped antivirals together, and knew that hydroxychloroquine and ivermectin were widely used. They must work differently than Mol.
They all have different MoAs. Hydroxychloroquine is assumed to operate mainly by targeting the endosomal route of the virus. It shows tropism form the endosomes, and when lysosomes bind they acidify the environment and that traps chloroquine analogues while also preventing the pH from dropping. This is assumed to help with SARS-COV2, especially the Omicrons since it stops them from being released inside the cell. There are other MoAs outlined in my Anthology Series on Hydroxychloroquine.
I didn't dive into Ivermectin but it's assumed several MoAs may be occurring, but I left that for others since that seemed to be something other people were already covering.
Edit: link to the series
https://moderndiscontent.substack.com/p/the-hydroxychloroquine-anthology-46b
Ah, thank you!
As I recall, Ivermectin works on infectious respiratory pathogens as a protease inhibitor that disrupts viral replication.