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The Hydroxychloroquine Anthology Series Archives
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The Anthology Series Archives

The Hydroxychloroquine Anthology Series Archives

A Collection of Posts about Hydroxychloroquine

Modern Discontent
Mar 1
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This post was copied and pasted over from Modern Discontent. If you are interested in Anthology Series posts as they come in or are interested in smaller posts along the way please consider subscribing over there as that is the main Substack. Also, paid-only content will only be available through becoming a paid member on Modern Discontent.

Hydroxychloroquine has been a highly contentious drug in the era of COVID. Because of this I thought it was pertinent to examine the drug and see if are any legitimate concerns over its possible side effects.


Part I: History and General Medicinal Properties

To start off, this post gives a good history of Quinine, starting from several centuries ago. The coming of the 20th Century, as well as two World Wars, lead to several innovations and the production of Chloroquine. Eventually, Hydroxychloroquine was synthesized in the 1950s and has seen continued use since then. There have been plenty of health properties related to Hydroxychloroquine, although there have been some noted toxicities.

Modern Discontent
Hydroxychloroquine: An Overview
Hydroxychloroquine has been part of the mainstream discourse since the beginning of the pandemic, with many countries adopting it’s usage at the beginning of the pandemic. However, the evidence around Hydroxychloroquine’s efficaciousness was murky, and unfortunately the utterance of the word by then President Donald Trump caused many to speak out against…
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6 months ago · 5 likes · 4 comments · Modern Discontent

Part II-1: Evidence as Treatment Against SARS-COV2

Here, we look at the use of Hydroxychloroquine against SARS-COV2. Along with some of the targets mentioned in Part I, I include another possible target. I then go into the evidence supporting combination therapy with Hydroxychloroquine with Zinc based on prior evidence of Hydroxychloroquine operating as an ionophore. Also, Azithromycin and Hydroxychloroquine may illicit a synergistic effect, although this is also likely to lead to a greater risk of adverse reactions.

Modern Discontent
Hydroxychloroquine: An Overview
Here, I’ll go into more detail about Hydroxychloroquine as a therapeutic against SARS-COV2. This will include a few more specific mechanisms of action, in vitro activity, pairing with zinc and Azythromicin, and examining the evidence in a clinical setting…
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6 months ago · 4 likes · 2 comments · Modern Discontent

Part II-2: Evidence as Treatment Against SARS-COV2 (Continued)

I provide one additional study that looked at all 3 therapeutics together (Hydroxychloroquine, Zinc, and Azithromycin). I then add some context to some of the meta-analyses and why it’s good to look at the studies included in such studies. Remember, therapeutics have a very specific window of effectiveness and both risks/benefits should be weighed to determine when and how much of a therapeutic is used.

Modern Discontent
Hydroxychloroquine: An Overview
Triple Threat- HCQ, Azithromycin and Zinc Combination Therapy So far many clinical studies conducted used a dual therapy of HCQ with either Zinc or Azithromycin. However, what would happen when all three are used together? The concern here would be whether there would be dangerous synergistic effects, but considering that Zinc is a vital mineral for our …
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6 months ago · 3 likes · 2 comments · Modern Discontent

Part III-1: Cardiac Arrhythmia, Media Hysteria, and Institutional Capture

Part of a paid Subscriber post, I dissect the information regarding Hydroxychloroquine’s cardiac arrhythmia concerns and see if the concerns are real or based predominately on media hysteria.

Modern Discontent
Hydroxychloroquine: An Overview
Although my Substack has highlighted a lot of concerns about the way science has been conducted over the course of the pandemic, I wasn’t always this skeptical. For the first few months of the pandemic I went along with everything that the media and Dr. Fauci presented, even when some questioning things started appearing (Concerns about tracking COVID into your house on your shoes, or microwaving take out after receiving the food were a few...”weird” things…
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6 months ago · 1 like · 2 comments · Modern Discontent

Part III-2: Cardiac Arrhythmia, Media Hysteria, and Institutional Capture (Continued)

Here, I summarize the information outlined in Part III-1 and give my perspective on Hydroxychloroquine. I also include citations for the papers I examined for the Paid Subscriber only content.

Modern Discontent
Hydroxychloroquine: An Overview
Piecing it Together One of the best phrases that encapsulates this situation is a phrase taken from The Darkhorse Podcast: “Welcome to Complex Systems”. We can see the extensive, nuanced interplay at work in regards to COVID, where the dynamics of medications, preexisting conditions, and illness all work together to lead to the COVID outcomes that we see…
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6 months ago · Modern Discontent
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