A question & heartfelt plea for you big brained re: neuroinvasion through the olfactory bulb• Healthy & unvaxxed, after prolonged exposure to my slightly covid-sick 18 yr old (home/quarantined from uni) I, of course, picked it up and had, untreated, only less than 24 hrs of a slight fever. However, I sustained total loss of my formerly incredibly sensitive olfactory senses. Over a yr later this loss has developed into the horrifying repugnant misrepresentation of many tastes and odors. I (wildly) suspect there is a connection to petroleum products having many notes and I can’t detect any but the base now? The citrusy perfume I always loved smells like axle grease as do many, many things taste now. I cannot bear eucalyptus, menthol, olive oil, sesame oil, arugula, red/green bell peppers, my old favorite moisturizer, etc… but most nightmarishly, myself! I am absolutely sickened by the smell of my own sweat. I’ve never been particularly sweaty & never used deodorant, always just powder, now I change my shirt 10X a day and I am self-conscious beyond words. I barely perspire but the tiniest bit is sickening to me. An Italian gardener and cook, I cannot smell flowers, I cannot smell what I’m cooking. after exposure to traffic or a restaurant kitchen I often smell a disgusting burning for days. For a while there, I thought maybe I was in ketosis and could only smell fat burning (this def’ly makes one crazy) but my diet though excellent is not that good and even if I don’t intermittent fast this is occurring and it seems to be getting worse. I take NAC, D& K, Quercetin, as I remember to. It is over a year now. Can you offer any wisdom or advice? A million thanks, blessings.
I have not had time to read this surely excellent analysis. I want to mention some things about inflammation which everyone should know.
There are multiple innate immune responses against viral, bacterial and fungal/yeast pathogens. However, these do not work much, or at all, against multicellular pathogens. Likewise, adaptive immune responses - the generation of antibodies, the antibodies themselves and the responses which destroy cells or viruses to which antibodies attach - work well on single cell and viral pathogen, but are not much use against multicellular pathogens.
So mammals (at least, I assume other vertebrates have it too) also have a gross cell-destroying set of immune responses which are capable of partly or completely destroying multicellular pathogens, AKA parasites. This is known as "inflammation". These inflammatory, indiscriminate, cell-destroying responses also may play some role in wound healing and in some responses to bacteria and viruses. However, they are primarily directed at parasites, such as helminths - intestinal worms.
For instance, eosinophils are the suicide bombers of the immune system. Their vacuoles contain enzymes which destroy DNA, RNA and proteins. When attracted to a site and triggered by inflammatory cytokines (signaling molecules released by immune cells, such as Th1 regulatory lymphocytes), the eosinophil disintegrates and lets loose its toxic payloads. Cells both of the host and the parasite are then destroyed, with other types of immune cells mopping up the debris.
There are numerous types of helminth. Many species of helminth have had it over us mammals for millions of years, so all our ancestors had one or more helminth infections for most of their lives. One way in which helminths have succeeded is by evolving the ability to exude compounds which downmodulate the host's inflammatory responses. There are an unknown number of these compounds, and at least two have been discovered. One is tuftsin-phosphorylcholine (TPC).
Hosts, including humans, have not evolved ways of ignoring these signaling molecules. Instead, our ancestors evolved _stronger_ inflammatory responses than are really needed, or healthy, to compensate for the ubiquitous down-modulation of such responses by one or more species of helminth. So without helminth infections, humans - with considerable individual genetic variation - are prone to having a stronger inflammatory response than is really healthy. This means that inflammation is often self-destructive. Sepsis is an obvious example. This kills 10 million people a year - and that was before COVID-19: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)32989-7/fulltext
Just over a century ago, we in developed nations got rid of our helminths. We did the same for our companion and agricultural animals as well - and probably also for our lab rats and other non-human animals used by researchers.
This is the primary reason for the vast swath of overly inflammatory illnesses, many of them auto-immune - triggered by (adaptive) immune responses to our own cells.
So far, no-one has made any of these compounds available as drugs to suppress excessive inflammation, but some people find it best to suppress their psoriasis, rheumatoid arthritis, Crohn's disease, life-threatening asthma by deliberately being infected by one of several relatively benign helminths. See https://helminthictherapywiki.org .
To make matters _much_ worse, most humans have only a 1/2 to 1/10th of the 50 ng/mL (125 nmol/L = 1 part in 20,000,000 by mass) circulating 25-hydroxyvitamin D their immune systems need to function properly. https://vitamindstopscovid.info/05-mds/
25-hydroxyvitamin D is an essential input (raw material, it is not a signaling molecule in itself) for immune cells (most types, as best we know, but also other types not related to the immune system) to run their internal (intracrine. also known as "autocrine") signaling system, which plays a major role in individual cells being able to change their behaviour in response to their changing circumstances. (Some of the signaling molecule - 1,25-dihydroxyvitamin D - can also diffuse from these cells and affect the behaviour of other cells nearby, typically of different types. This is paracrine signaling.) See: https://vitamindstopscovid.info/02-autocrine/ .
So most humans have the double-whammy of lack of helminths and grossly inadequate vitamin D3 intakes (UV-B on the skin can make it too, but this damages DNA and so causes skin cancer - and there is very little in food or multivitamins) with resultant immune system dysregulation and general dysfunction due to lousy circulating 25-hydroxyvitamin D levels.
Virtually no researchers - including vitamin D researchers - recognise the problems caused by lack of helminths. Some vitamin D researchers are on the case of excessive inflammation - see Chauss et al. 2021 on Th1 regulatory lymphocytes from the lungs of hospitalised COVID-19 patients: https://aminotheory.com/cv19/icu/#2021-Chauss. However not one of them AFAIK discuss lack of helminths. Lots of researchers into inflammatory disorders (dozens or hundreds of disorders) don't think about either vitamin D or lack of helminths. The few people researching helminths and inflammation don't seem to think about lousy 25-hydroxyvitamin D levels.
Please bear all this in mind when discussing inflammation in humans, experimental animals (probably low vitamin D, surely without helminths) and our companion and agricultural animals. (Indoor agricultural animals often get decent vitamin D3 intakes - this is what most manufactured vitamin D3 cholecalciferol is used for. They die or do not produce food properly if they are deficient.)
For reasons unknown, higher than 50 ng/mL 25-hydroxyvitamin D levels can suppress the excessive inflammation of psoriasis, MS, rheumatoid arthritis etc. See the research articles cited at: https://vitamindstopscovid.info/06-adv/ - including those on helminths.
If most people had helminths and proper vitamin D3 intakes, such as 0.125 mg 5000 IU a day for 70 kg bodyweight, there would be a lot less trouble with excessive inflammation. Then these so-called vaccines against SARS-CoV-2 would probably cause less trouble, in some respects at least.
Then, there would be little reason to bother with such quasi-vaccines because few people infected with SARS-CoV-2 would become seriously ill. Those infected would shed less viruses in general and so overall rates of transmission would be very much lower than today - probably to the point of the disease not spreading very much.
However, 5000 IU a day is a gram every 22 years, and pharma grade vitamin D3 costs USD$2.50 a gram, ex-factory - so where's the profit in that??
I am still surprised that there is no widespread discussion of vaccine LNPs in the context of CARPA or complement activated pseudoallergy. LNPs have been around as vehicle in pharmaceuticals. CARPA doesn't respond to an EpiPen. Far more inflammatory and long lasting. I knew this was something that precluded my getting this particular product from the moment I heard that the mRNA was encapsulated by LNPs. It is part of the story of the toxicity of the vaccines.
LNPs and complement reactions also an issue in nanomedicines. Contrast media. Infused ABs.
So, I didn't take the time to read the stuffy, but collating what you've d said with other readings, andfree floating mind at work. We know the LPNs she'd from the jabbed population. Some of the LPNs have reassembled, contain mRNA, and then transfer in the environment to me, or you, or....
So the future of self replicating "vaccines" is at hand.
I'm still weak on endosomes, but it seems to me that there's some paradox that ensures that ionizable lipids can't be toxic since they are only positive if in an endosome. So even though thy fuse with the endosome via acquiring the positive charge in the endosome, they can't "escape" it without losing charge, even if somehow they keep being cycled back into more endosomes or other membranes. Trippy.
The sponging effect interesting. Some writers, I recall, who specialize in obesity and metabolic disorders, saw the deposits of fats in unusual areas as ways of sequestering dangerous amounts of lipids in places that will protect the person from their existence.
A question & heartfelt plea for you big brained re: neuroinvasion through the olfactory bulb• Healthy & unvaxxed, after prolonged exposure to my slightly covid-sick 18 yr old (home/quarantined from uni) I, of course, picked it up and had, untreated, only less than 24 hrs of a slight fever. However, I sustained total loss of my formerly incredibly sensitive olfactory senses. Over a yr later this loss has developed into the horrifying repugnant misrepresentation of many tastes and odors. I (wildly) suspect there is a connection to petroleum products having many notes and I can’t detect any but the base now? The citrusy perfume I always loved smells like axle grease as do many, many things taste now. I cannot bear eucalyptus, menthol, olive oil, sesame oil, arugula, red/green bell peppers, my old favorite moisturizer, etc… but most nightmarishly, myself! I am absolutely sickened by the smell of my own sweat. I’ve never been particularly sweaty & never used deodorant, always just powder, now I change my shirt 10X a day and I am self-conscious beyond words. I barely perspire but the tiniest bit is sickening to me. An Italian gardener and cook, I cannot smell flowers, I cannot smell what I’m cooking. after exposure to traffic or a restaurant kitchen I often smell a disgusting burning for days. For a while there, I thought maybe I was in ketosis and could only smell fat burning (this def’ly makes one crazy) but my diet though excellent is not that good and even if I don’t intermittent fast this is occurring and it seems to be getting worse. I take NAC, D& K, Quercetin, as I remember to. It is over a year now. Can you offer any wisdom or advice? A million thanks, blessings.
I have not had time to read this surely excellent analysis. I want to mention some things about inflammation which everyone should know.
There are multiple innate immune responses against viral, bacterial and fungal/yeast pathogens. However, these do not work much, or at all, against multicellular pathogens. Likewise, adaptive immune responses - the generation of antibodies, the antibodies themselves and the responses which destroy cells or viruses to which antibodies attach - work well on single cell and viral pathogen, but are not much use against multicellular pathogens.
So mammals (at least, I assume other vertebrates have it too) also have a gross cell-destroying set of immune responses which are capable of partly or completely destroying multicellular pathogens, AKA parasites. This is known as "inflammation". These inflammatory, indiscriminate, cell-destroying responses also may play some role in wound healing and in some responses to bacteria and viruses. However, they are primarily directed at parasites, such as helminths - intestinal worms.
For instance, eosinophils are the suicide bombers of the immune system. Their vacuoles contain enzymes which destroy DNA, RNA and proteins. When attracted to a site and triggered by inflammatory cytokines (signaling molecules released by immune cells, such as Th1 regulatory lymphocytes), the eosinophil disintegrates and lets loose its toxic payloads. Cells both of the host and the parasite are then destroyed, with other types of immune cells mopping up the debris.
There are numerous types of helminth. Many species of helminth have had it over us mammals for millions of years, so all our ancestors had one or more helminth infections for most of their lives. One way in which helminths have succeeded is by evolving the ability to exude compounds which downmodulate the host's inflammatory responses. There are an unknown number of these compounds, and at least two have been discovered. One is tuftsin-phosphorylcholine (TPC).
Hosts, including humans, have not evolved ways of ignoring these signaling molecules. Instead, our ancestors evolved _stronger_ inflammatory responses than are really needed, or healthy, to compensate for the ubiquitous down-modulation of such responses by one or more species of helminth. So without helminth infections, humans - with considerable individual genetic variation - are prone to having a stronger inflammatory response than is really healthy. This means that inflammation is often self-destructive. Sepsis is an obvious example. This kills 10 million people a year - and that was before COVID-19: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)32989-7/fulltext
Just over a century ago, we in developed nations got rid of our helminths. We did the same for our companion and agricultural animals as well - and probably also for our lab rats and other non-human animals used by researchers.
This is the primary reason for the vast swath of overly inflammatory illnesses, many of them auto-immune - triggered by (adaptive) immune responses to our own cells.
So far, no-one has made any of these compounds available as drugs to suppress excessive inflammation, but some people find it best to suppress their psoriasis, rheumatoid arthritis, Crohn's disease, life-threatening asthma by deliberately being infected by one of several relatively benign helminths. See https://helminthictherapywiki.org .
To make matters _much_ worse, most humans have only a 1/2 to 1/10th of the 50 ng/mL (125 nmol/L = 1 part in 20,000,000 by mass) circulating 25-hydroxyvitamin D their immune systems need to function properly. https://vitamindstopscovid.info/05-mds/
25-hydroxyvitamin D is an essential input (raw material, it is not a signaling molecule in itself) for immune cells (most types, as best we know, but also other types not related to the immune system) to run their internal (intracrine. also known as "autocrine") signaling system, which plays a major role in individual cells being able to change their behaviour in response to their changing circumstances. (Some of the signaling molecule - 1,25-dihydroxyvitamin D - can also diffuse from these cells and affect the behaviour of other cells nearby, typically of different types. This is paracrine signaling.) See: https://vitamindstopscovid.info/02-autocrine/ .
So most humans have the double-whammy of lack of helminths and grossly inadequate vitamin D3 intakes (UV-B on the skin can make it too, but this damages DNA and so causes skin cancer - and there is very little in food or multivitamins) with resultant immune system dysregulation and general dysfunction due to lousy circulating 25-hydroxyvitamin D levels.
Virtually no researchers - including vitamin D researchers - recognise the problems caused by lack of helminths. Some vitamin D researchers are on the case of excessive inflammation - see Chauss et al. 2021 on Th1 regulatory lymphocytes from the lungs of hospitalised COVID-19 patients: https://aminotheory.com/cv19/icu/#2021-Chauss. However not one of them AFAIK discuss lack of helminths. Lots of researchers into inflammatory disorders (dozens or hundreds of disorders) don't think about either vitamin D or lack of helminths. The few people researching helminths and inflammation don't seem to think about lousy 25-hydroxyvitamin D levels.
Please bear all this in mind when discussing inflammation in humans, experimental animals (probably low vitamin D, surely without helminths) and our companion and agricultural animals. (Indoor agricultural animals often get decent vitamin D3 intakes - this is what most manufactured vitamin D3 cholecalciferol is used for. They die or do not produce food properly if they are deficient.)
For reasons unknown, higher than 50 ng/mL 25-hydroxyvitamin D levels can suppress the excessive inflammation of psoriasis, MS, rheumatoid arthritis etc. See the research articles cited at: https://vitamindstopscovid.info/06-adv/ - including those on helminths.
If most people had helminths and proper vitamin D3 intakes, such as 0.125 mg 5000 IU a day for 70 kg bodyweight, there would be a lot less trouble with excessive inflammation. Then these so-called vaccines against SARS-CoV-2 would probably cause less trouble, in some respects at least.
Then, there would be little reason to bother with such quasi-vaccines because few people infected with SARS-CoV-2 would become seriously ill. Those infected would shed less viruses in general and so overall rates of transmission would be very much lower than today - probably to the point of the disease not spreading very much.
However, 5000 IU a day is a gram every 22 years, and pharma grade vitamin D3 costs USD$2.50 a gram, ex-factory - so where's the profit in that??
I am still surprised that there is no widespread discussion of vaccine LNPs in the context of CARPA or complement activated pseudoallergy. LNPs have been around as vehicle in pharmaceuticals. CARPA doesn't respond to an EpiPen. Far more inflammatory and long lasting. I knew this was something that precluded my getting this particular product from the moment I heard that the mRNA was encapsulated by LNPs. It is part of the story of the toxicity of the vaccines.
LNPs and complement reactions also an issue in nanomedicines. Contrast media. Infused ABs.
https://pubmed.ncbi.nlm.nih.gov/31275462/
https://pubmed.ncbi.nlm.nih.gov/31544866/
So, I didn't take the time to read the stuffy, but collating what you've d said with other readings, andfree floating mind at work. We know the LPNs she'd from the jabbed population. Some of the LPNs have reassembled, contain mRNA, and then transfer in the environment to me, or you, or....
So the future of self replicating "vaccines" is at hand.
I'm still weak on endosomes, but it seems to me that there's some paradox that ensures that ionizable lipids can't be toxic since they are only positive if in an endosome. So even though thy fuse with the endosome via acquiring the positive charge in the endosome, they can't "escape" it without losing charge, even if somehow they keep being cycled back into more endosomes or other membranes. Trippy.
The sponging effect interesting. Some writers, I recall, who specialize in obesity and metabolic disorders, saw the deposits of fats in unusual areas as ways of sequestering dangerous amounts of lipids in places that will protect the person from their existence.