A question & heartfelt plea for you big brained re: neuroinvasion through the olfactory bulb• Healthy & unvaxxed, after prolonged exposure to my slightly covid-sick 18 yr old (home/quarantined from uni) I, of course, picked it up and had, untreated, only less than 24 hrs of a slight fever. However, I sustained total loss of my formerly incredibly sensitive olfactory senses. Over a yr later this loss has developed into the horrifying repugnant misrepresentation of many tastes and odors. I (wildly) suspect there is a connection to petroleum products having many notes and I can’t detect any but the base now? The citrusy perfume I always loved smells like axle grease as do many, many things taste now. I cannot bear eucalyptus, menthol, olive oil, sesame oil, arugula, red/green bell peppers, my old favorite moisturizer, etc… but most nightmarishly, myself! I am absolutely sickened by the smell of my own sweat. I’ve never been particularly sweaty & never used deodorant, always just powder, now I change my shirt 10X a day and I am self-conscious beyond words. I barely perspire but the tiniest bit is sickening to me. An Italian gardener and cook, I cannot smell flowers, I cannot smell what I’m cooking. after exposure to traffic or a restaurant kitchen I often smell a disgusting burning for days. For a while there, I thought maybe I was in ketosis and could only smell fat burning (this def’ly makes one crazy) but my diet though excellent is not that good and even if I don’t intermittent fast this is occurring and it seems to be getting worse. I take NAC, D& K, Quercetin, as I remember to. It is over a year now. Can you offer any wisdom or advice? A million thanks, blessings.
Hi Karen, I'm sorry you're going through that. It's very interesting because so many people who suffer from anosmia appear to have issues with fatty foods and smells, so I wonder why that may be.
As to the research for neuroinvasion, I haven't quite kept up with it. I believe preliminary data assumed that SARS-COV2 may gain entryway through the olfactory bulb and enter into the CNS. There was some debate about whether the olfactory bulb was targeted directly. However, the most recent articles I saw was one where they examined cadavers and found that it was actually cells peripheral to the olfactory bulb that was targeted. So the bulb is mostly unharmed, but damage to peripheral cells may alter signaling pathways which may be attributing to the issues with smells.
I'm not a medical professional, so I can't offer any medical advice specifically, although as Betsy mentioned there may be help with an FLCCC protocol. I have heard that corticosteroids may help as well. Either way the best thing to do may be to find research about anosmia and possible treatments, and then speak to a physician about your options. I believe as long as you enter into the conversation as an informed patient and are not talked down to you may be able to get some good information.
I would be miserable too, my sense of smell is like a hound.
If it were me, I would see one of the frontline doctors who have added long haul and vax injury to their practices. FLCCC has protocols that are being continually updated for these syndromes with input from other expert teams that includes both Rx and OTC modes.
Interestingly a set of OTC + Rx compounds mentioned address mast cell activation which might be a chronic problem influencing nerves. For many reasons ivermectin is yet again a champion in resolving lingering problems.
Some of the treatments used by people with chronic or hard to treat tick borne illness symptoms that are neurological include minocycline for brain inflammation (TLR4 and glial activation calming); minocycline unlike the other tetracyclines gets into the brain and the fatty membranes of nerves. This is showing up in the literature for COVID with a decent number of articles Do some searching yourself in PubMed and you will find some gold mine ideas, with minocycline set in a context of a handful of other approaches to improve for example:
Similarly Low dose naltrexone (LDN) is widely used and incredibly safe and is showing up on these COVID protocols. It enjoys wide success in chronic inflammatory illnesses and autoimmune conditions. Lots of mechanisms of action including TLRs and other inflammatory processes.
Many of these remedies work well together and are benign in terms of side effects or safety issues. It would be a shame not to plunge in and get some help. But time may be of the essence, and the longer something goes the harder it may be to treat or repair. Sense of smell may just be the tip of an iceberg, you may not yet be seeing more concerning issues that are brewing.
I have two relatives who both benefitted from following FLCCC ideas-one had constant skin rash with itching resulting tiny scabs and retinal bleeding, the other is having headaches and stamina problems. The latter of my relatives is registering this week for Dr. Pierre Kory's telehealth practice to access more of the items in the protocol as needed and for testing and monitoring. Here is information about Kory's practice, which includes some very experienced nurse practitioners. I understand they have telehealth in all states.
Yess-a profound connection to the world is just simply gone! Alas, the distortion, though, is crazy-making. I cannot believe I’ll gag at the smell of myself for the rest of my life, I am very grateful for your gift of hope. Please forgive me for complaining when so many are in much worse straits in this mess. Thank you for understanding! God bless you.
Many people get their sense of smell back after a course of ivermectin. You might get with Dr. Kory or Dr. Marik over at FLCCC: Dr Kory is on substack. Dr Keith Berkowitz (I believe that's his name) works with many SARS2/vax injured, too. I had scent distortions after West Nile, gives me a bit of understanding. Mine mostly resolved after a year. I can't imagine the hell you are living with; I am so sorry, that is awful. I hope one or more of these folks can help you with it.
Much heartfelt gratitude Potatodots. With impetus from the hope & encouragement I’ve received from you & the other likewise beautiful, empathetic souls here, I found a wonderful functional med Dr, and am noticing small improvement already, after only a couple of days on the Rx wh can’t be mentioned and LDN. Know you are all lifelines, hands of blessed light which thus will prevail in this darkness…
I have not had time to read this surely excellent analysis. I want to mention some things about inflammation which everyone should know.
There are multiple innate immune responses against viral, bacterial and fungal/yeast pathogens. However, these do not work much, or at all, against multicellular pathogens. Likewise, adaptive immune responses - the generation of antibodies, the antibodies themselves and the responses which destroy cells or viruses to which antibodies attach - work well on single cell and viral pathogen, but are not much use against multicellular pathogens.
So mammals (at least, I assume other vertebrates have it too) also have a gross cell-destroying set of immune responses which are capable of partly or completely destroying multicellular pathogens, AKA parasites. This is known as "inflammation". These inflammatory, indiscriminate, cell-destroying responses also may play some role in wound healing and in some responses to bacteria and viruses. However, they are primarily directed at parasites, such as helminths - intestinal worms.
For instance, eosinophils are the suicide bombers of the immune system. Their vacuoles contain enzymes which destroy DNA, RNA and proteins. When attracted to a site and triggered by inflammatory cytokines (signaling molecules released by immune cells, such as Th1 regulatory lymphocytes), the eosinophil disintegrates and lets loose its toxic payloads. Cells both of the host and the parasite are then destroyed, with other types of immune cells mopping up the debris.
There are numerous types of helminth. Many species of helminth have had it over us mammals for millions of years, so all our ancestors had one or more helminth infections for most of their lives. One way in which helminths have succeeded is by evolving the ability to exude compounds which downmodulate the host's inflammatory responses. There are an unknown number of these compounds, and at least two have been discovered. One is tuftsin-phosphorylcholine (TPC).
Hosts, including humans, have not evolved ways of ignoring these signaling molecules. Instead, our ancestors evolved _stronger_ inflammatory responses than are really needed, or healthy, to compensate for the ubiquitous down-modulation of such responses by one or more species of helminth. So without helminth infections, humans - with considerable individual genetic variation - are prone to having a stronger inflammatory response than is really healthy. This means that inflammation is often self-destructive. Sepsis is an obvious example. This kills 10 million people a year - and that was before COVID-19: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)32989-7/fulltext
Just over a century ago, we in developed nations got rid of our helminths. We did the same for our companion and agricultural animals as well - and probably also for our lab rats and other non-human animals used by researchers.
This is the primary reason for the vast swath of overly inflammatory illnesses, many of them auto-immune - triggered by (adaptive) immune responses to our own cells.
So far, no-one has made any of these compounds available as drugs to suppress excessive inflammation, but some people find it best to suppress their psoriasis, rheumatoid arthritis, Crohn's disease, life-threatening asthma by deliberately being infected by one of several relatively benign helminths. See https://helminthictherapywiki.org .
To make matters _much_ worse, most humans have only a 1/2 to 1/10th of the 50 ng/mL (125 nmol/L = 1 part in 20,000,000 by mass) circulating 25-hydroxyvitamin D their immune systems need to function properly. https://vitamindstopscovid.info/05-mds/
25-hydroxyvitamin D is an essential input (raw material, it is not a signaling molecule in itself) for immune cells (most types, as best we know, but also other types not related to the immune system) to run their internal (intracrine. also known as "autocrine") signaling system, which plays a major role in individual cells being able to change their behaviour in response to their changing circumstances. (Some of the signaling molecule - 1,25-dihydroxyvitamin D - can also diffuse from these cells and affect the behaviour of other cells nearby, typically of different types. This is paracrine signaling.) See: https://vitamindstopscovid.info/02-autocrine/ .
So most humans have the double-whammy of lack of helminths and grossly inadequate vitamin D3 intakes (UV-B on the skin can make it too, but this damages DNA and so causes skin cancer - and there is very little in food or multivitamins) with resultant immune system dysregulation and general dysfunction due to lousy circulating 25-hydroxyvitamin D levels.
Virtually no researchers - including vitamin D researchers - recognise the problems caused by lack of helminths. Some vitamin D researchers are on the case of excessive inflammation - see Chauss et al. 2021 on Th1 regulatory lymphocytes from the lungs of hospitalised COVID-19 patients: https://aminotheory.com/cv19/icu/#2021-Chauss. However not one of them AFAIK discuss lack of helminths. Lots of researchers into inflammatory disorders (dozens or hundreds of disorders) don't think about either vitamin D or lack of helminths. The few people researching helminths and inflammation don't seem to think about lousy 25-hydroxyvitamin D levels.
Please bear all this in mind when discussing inflammation in humans, experimental animals (probably low vitamin D, surely without helminths) and our companion and agricultural animals. (Indoor agricultural animals often get decent vitamin D3 intakes - this is what most manufactured vitamin D3 cholecalciferol is used for. They die or do not produce food properly if they are deficient.)
For reasons unknown, higher than 50 ng/mL 25-hydroxyvitamin D levels can suppress the excessive inflammation of psoriasis, MS, rheumatoid arthritis etc. See the research articles cited at: https://vitamindstopscovid.info/06-adv/ - including those on helminths.
If most people had helminths and proper vitamin D3 intakes, such as 0.125 mg 5000 IU a day for 70 kg bodyweight, there would be a lot less trouble with excessive inflammation. Then these so-called vaccines against SARS-CoV-2 would probably cause less trouble, in some respects at least.
Then, there would be little reason to bother with such quasi-vaccines because few people infected with SARS-CoV-2 would become seriously ill. Those infected would shed less viruses in general and so overall rates of transmission would be very much lower than today - probably to the point of the disease not spreading very much.
However, 5000 IU a day is a gram every 22 years, and pharma grade vitamin D3 costs USD$2.50 a gram, ex-factory - so where's the profit in that??
Hey Robin! I've been wondering where you've been and I'm glad to see you're OK. I've heard of the helminth hypothesis in relation to controlled immunity. It's really fascinating, especially considering we're at the point where we are examining the effects of bacteria and possibly viruses on our biological processes. It would be quite ironic if the push for Ivermectin may actually end up detrimental because of the effects on helminths, although I will also say I don't know much about the research.
Have you seen Brett and Heather's recent Darkhorse podcast where they discuss intracellular melatonin being made in near IR light? I thought it was fascinating and adds to the overall reason as to why we should be outside.
Helminths a strategic actor within a diverse and healthy microbiome. I have read about this before. Big farming and the use of all sorts of chemicals would reduce healthy contact with microbiome on plants.
Vitamin D is a more complicated subject when looking at inflammation. It can be immunosupressive and reduce symptoms which may be great in treating leftover inflammation from a virus defeated, but can be problematic with chronic infections like the tickborne. The active form of vitamin D - 1,25 Dihydroxyvitamin D can be present in high quantities while the inactive reservoir is low during an infection. At key points you don't want to be dousing the system with more exogenous D. This timing awareness of monitoring and using or not using D is important to understand in managing more chronic infections.
I've read about that when doing my first look into Vitamin D. The research appears highly conflicting since it depends upon the type of precursor molecule, the bioavailability of exogenous Vitamin D, which cells take up which forms, which form gets used by cells and used during an infection, and which form is checked when looking for Vitamin D levels. Honestly, it all gave me a bit of a headache!
Hi Betsy, I read some of this work - Albert, Proal and Marshall's 2009 "Vitamin D: the alternative hypothesis" a few years ago. It makes no sense to me. I don't have time to write a critique and this is not the place for it, but I know of no vitamin D researchers who refer to this and related work.
Good supplies of 25-hydroxyvitamin D are needed so immune cells can run their intreacellular (intracine) and to nearby cells (paracrine) signaling systems properly. They need to do this in order to respond to their changing circumstances. This is unrelated to hormonal 1,25-dihydroxyvitamin D. Please see: What every MD, immunologist, virologist and epidemiologist should know about vitamin D and the immune system https://vitamindstopscovid.info/05-mds/ .
I understand that literature is large and complex. This is an alternative way of understanding and accommodating the same data. Vitamin D can act like a steroid and be helpful and also prevents and intervenes in many problems. But there is a vitamin D reversal condition that can happen in inflammatory disease. It happened to me and it is well known by good rheumatologists. Addressing elevated levels of 1,25 dihydroxycholecalciferol vitamin D (calcitriol) which can be inflammatory until one gets well does work almost miraculously if that reversal is part of the problem. It is important when advising everyone to dose up on more and more Vitamin D to understand that some additional testing for the active form and confirming that there isn't a reversal syndrome going on would be important to understand in people who are sick. When one has too much calcitriol (the body's defense being activated against a pathogen) it seems to know to lower the pool of inactive D, the stuff we take in the supplements. It seems that is a natural balancing act that we need to be careful not to disrupt at specific time frames in an illness. But Dr. Proal is really the expert on this topic.
I am still surprised that there is no widespread discussion of vaccine LNPs in the context of CARPA or complement activated pseudoallergy. LNPs have been around as vehicle in pharmaceuticals. CARPA doesn't respond to an EpiPen. Far more inflammatory and long lasting. I knew this was something that precluded my getting this particular product from the moment I heard that the mRNA was encapsulated by LNPs. It is part of the story of the toxicity of the vaccines.
LNPs and complement reactions also an issue in nanomedicines. Contrast media. Infused ABs.
I haven't heard of CARPA before, so thanks for pointing me to that. I'll see if I can find additional articles. There was a lot of talk about PEG being immunogenic, but I am not sure how extensive the anti-PEG response is, or what the effects are really. It'd be pretty interesting if the vaccines had reduced efficacy because of the prevalence of anti-PEG antibodies in the population.
Yes there are dozens of papers on CARPA and the toxicity and immumogencity of nanolipids and nanomedicines. in PubMed and check ResearchGate. I knew something was wrong when everyone kept talking about anaphylaxis and not CARPA. Treatments are different, CARPA more difficult to manage. The media talked about this as something simple handled with an Epi-Pen as if even anaphylaxis was trivial. If this is your area someone should write a paper on this being unrecognized--and I think on purpose.
So, I didn't take the time to read the stuffy, but collating what you've d said with other readings, andfree floating mind at work. We know the LPNs she'd from the jabbed population. Some of the LPNs have reassembled, contain mRNA, and then transfer in the environment to me, or you, or....
So the future of self replicating "vaccines" is at hand.
Well I'm not quite sure the LNPs are being shed, but I've heard people mention spike protein shedding although I don't find much evidence of it occurring aside from anecdotal evidence. It also may be rather difficult to wrap up the mRNA again and release them to wreak some more havoc. I think there may be a few steps to being able to release LNPs in the air.
It turned out that vaxxed parents actively shed vaccine-produced particles onto their children so that the kids acquired “humoral immunity” following shedding from their parents! Not only was this finding evident in the data, it actually was STRONGLY statistically significant with p-value of 0.01! This means that this was not a chance finding.
I saw that post, but the study was very small and did not elaborate too much. One experiment took masks from lab employees and checked for antibodies. Then they took nasal swabs in households and checked family members. The big issue is that we don't know the status of the people within that household and if they were sick prior to vaccination or not. We just know their status at the time, and the researchers just mention "SARS-COV2 antibodies", what antibodies to what antigens? I'm not sure, but if it was only anti-spike then maybe we can make an assumption.
We also don't know "what" is being shed. The researchers assume it's antibodies, Igor assumes it's the spike, and I think the study isn't well-controlled enough to discern anything.
I think it's an interesting starting point, but I would need to see more evidence before making any assumptions.
I'm still weak on endosomes, but it seems to me that there's some paradox that ensures that ionizable lipids can't be toxic since they are only positive if in an endosome. So even though thy fuse with the endosome via acquiring the positive charge in the endosome, they can't "escape" it without losing charge, even if somehow they keep being cycled back into more endosomes or other membranes. Trippy.
I'm still trying to figure this out, since this behavior will be akin to fluvoxamine or chloroquine derivatives and their lysosomotropic behavior. Typical amines have a pKa around 9 so they should be protonated at physiological pH. However, these tertiary amines may actually have a pKa near 7, possibly due to donation of electron density through the sigma bonds of the carbon chains conferring greater stability of cation formation.
If that's the case then they are likely to be neutral at physiological pH, enter into endosomes, become positively charged, and I suppose charge repulsion may cause the lipids to break apart and release the mRNA?
Which begs the question as to why they may interact with membranes in the first place if they aren't fully cationic in nature. There are a few quaternary lipids in the formulation, so I suppose there's that as well as something called the zeta potential at play that may cause them to favor membrane fusion. Honestly, this field of research appears to still be in its early stages and so many things haven't quite been sorted out yet.
The sponging effect interesting. Some writers, I recall, who specialize in obesity and metabolic disorders, saw the deposits of fats in unusual areas as ways of sequestering dangerous amounts of lipids in places that will protect the person from their existence.
I mentioned it more for some inquiry since it may be something rather interesting. I've seen several people bring up this idea before so it's probably been around for quite some time. It would actually be paradoxical if obese people were more protected from adverse vaccine reactions while healthy people would be better protected against the infection.
Well, I don't have any knowledge on this topic since I'm just providing a rather superficial hypothesis, but do you have any insight into this possibility? The main factor would be the degradation of the ionizable lipids, but acid-based ester hydrolysis is rather difficult and I am unaware of regions in the body that are highly basic. The liver should be able to hydrolyze the ester links, and if that's a big concern it may be worth considering utilizing the "first pass effect" to get the lipids to degrade quickly.
A question & heartfelt plea for you big brained re: neuroinvasion through the olfactory bulb• Healthy & unvaxxed, after prolonged exposure to my slightly covid-sick 18 yr old (home/quarantined from uni) I, of course, picked it up and had, untreated, only less than 24 hrs of a slight fever. However, I sustained total loss of my formerly incredibly sensitive olfactory senses. Over a yr later this loss has developed into the horrifying repugnant misrepresentation of many tastes and odors. I (wildly) suspect there is a connection to petroleum products having many notes and I can’t detect any but the base now? The citrusy perfume I always loved smells like axle grease as do many, many things taste now. I cannot bear eucalyptus, menthol, olive oil, sesame oil, arugula, red/green bell peppers, my old favorite moisturizer, etc… but most nightmarishly, myself! I am absolutely sickened by the smell of my own sweat. I’ve never been particularly sweaty & never used deodorant, always just powder, now I change my shirt 10X a day and I am self-conscious beyond words. I barely perspire but the tiniest bit is sickening to me. An Italian gardener and cook, I cannot smell flowers, I cannot smell what I’m cooking. after exposure to traffic or a restaurant kitchen I often smell a disgusting burning for days. For a while there, I thought maybe I was in ketosis and could only smell fat burning (this def’ly makes one crazy) but my diet though excellent is not that good and even if I don’t intermittent fast this is occurring and it seems to be getting worse. I take NAC, D& K, Quercetin, as I remember to. It is over a year now. Can you offer any wisdom or advice? A million thanks, blessings.
Hi Karen, I'm sorry you're going through that. It's very interesting because so many people who suffer from anosmia appear to have issues with fatty foods and smells, so I wonder why that may be.
As to the research for neuroinvasion, I haven't quite kept up with it. I believe preliminary data assumed that SARS-COV2 may gain entryway through the olfactory bulb and enter into the CNS. There was some debate about whether the olfactory bulb was targeted directly. However, the most recent articles I saw was one where they examined cadavers and found that it was actually cells peripheral to the olfactory bulb that was targeted. So the bulb is mostly unharmed, but damage to peripheral cells may alter signaling pathways which may be attributing to the issues with smells.
I'm not a medical professional, so I can't offer any medical advice specifically, although as Betsy mentioned there may be help with an FLCCC protocol. I have heard that corticosteroids may help as well. Either way the best thing to do may be to find research about anosmia and possible treatments, and then speak to a physician about your options. I believe as long as you enter into the conversation as an informed patient and are not talked down to you may be able to get some good information.
Thank you so much. God bless you.
I would be miserable too, my sense of smell is like a hound.
If it were me, I would see one of the frontline doctors who have added long haul and vax injury to their practices. FLCCC has protocols that are being continually updated for these syndromes with input from other expert teams that includes both Rx and OTC modes.
Interestingly a set of OTC + Rx compounds mentioned address mast cell activation which might be a chronic problem influencing nerves. For many reasons ivermectin is yet again a champion in resolving lingering problems.
Some of the treatments used by people with chronic or hard to treat tick borne illness symptoms that are neurological include minocycline for brain inflammation (TLR4 and glial activation calming); minocycline unlike the other tetracyclines gets into the brain and the fatty membranes of nerves. This is showing up in the literature for COVID with a decent number of articles Do some searching yourself in PubMed and you will find some gold mine ideas, with minocycline set in a context of a handful of other approaches to improve for example:
https://pubmed.ncbi.nlm.nih.gov/35317886/
Similarly Low dose naltrexone (LDN) is widely used and incredibly safe and is showing up on these COVID protocols. It enjoys wide success in chronic inflammatory illnesses and autoimmune conditions. Lots of mechanisms of action including TLRs and other inflammatory processes.
https://pubmed.ncbi.nlm.nih.gov/35179184/
https://pubmed.ncbi.nlm.nih.gov/32930058/
Many of these remedies work well together and are benign in terms of side effects or safety issues. It would be a shame not to plunge in and get some help. But time may be of the essence, and the longer something goes the harder it may be to treat or repair. Sense of smell may just be the tip of an iceberg, you may not yet be seeing more concerning issues that are brewing.
I have two relatives who both benefitted from following FLCCC ideas-one had constant skin rash with itching resulting tiny scabs and retinal bleeding, the other is having headaches and stamina problems. The latter of my relatives is registering this week for Dr. Pierre Kory's telehealth practice to access more of the items in the protocol as needed and for testing and monitoring. Here is information about Kory's practice, which includes some very experienced nurse practitioners. I understand they have telehealth in all states.
https://pierrekory.substack.com/p/dear-subscribers-i-am-opening-a-covid?r=c8vqx&s=r&utm_campaign=post&utm_medium=web
There is hope!
Yess-a profound connection to the world is just simply gone! Alas, the distortion, though, is crazy-making. I cannot believe I’ll gag at the smell of myself for the rest of my life, I am very grateful for your gift of hope. Please forgive me for complaining when so many are in much worse straits in this mess. Thank you for understanding! God bless you.
Many people get their sense of smell back after a course of ivermectin. You might get with Dr. Kory or Dr. Marik over at FLCCC: Dr Kory is on substack. Dr Keith Berkowitz (I believe that's his name) works with many SARS2/vax injured, too. I had scent distortions after West Nile, gives me a bit of understanding. Mine mostly resolved after a year. I can't imagine the hell you are living with; I am so sorry, that is awful. I hope one or more of these folks can help you with it.
Much heartfelt gratitude Potatodots. With impetus from the hope & encouragement I’ve received from you & the other likewise beautiful, empathetic souls here, I found a wonderful functional med Dr, and am noticing small improvement already, after only a couple of days on the Rx wh can’t be mentioned and LDN. Know you are all lifelines, hands of blessed light which thus will prevail in this darkness…
I'm glad to hear you are doing better Karen! I hope you can get your full smell back eventually and enjoy all those perfumes and flowers once again!
I have not had time to read this surely excellent analysis. I want to mention some things about inflammation which everyone should know.
There are multiple innate immune responses against viral, bacterial and fungal/yeast pathogens. However, these do not work much, or at all, against multicellular pathogens. Likewise, adaptive immune responses - the generation of antibodies, the antibodies themselves and the responses which destroy cells or viruses to which antibodies attach - work well on single cell and viral pathogen, but are not much use against multicellular pathogens.
So mammals (at least, I assume other vertebrates have it too) also have a gross cell-destroying set of immune responses which are capable of partly or completely destroying multicellular pathogens, AKA parasites. This is known as "inflammation". These inflammatory, indiscriminate, cell-destroying responses also may play some role in wound healing and in some responses to bacteria and viruses. However, they are primarily directed at parasites, such as helminths - intestinal worms.
For instance, eosinophils are the suicide bombers of the immune system. Their vacuoles contain enzymes which destroy DNA, RNA and proteins. When attracted to a site and triggered by inflammatory cytokines (signaling molecules released by immune cells, such as Th1 regulatory lymphocytes), the eosinophil disintegrates and lets loose its toxic payloads. Cells both of the host and the parasite are then destroyed, with other types of immune cells mopping up the debris.
There are numerous types of helminth. Many species of helminth have had it over us mammals for millions of years, so all our ancestors had one or more helminth infections for most of their lives. One way in which helminths have succeeded is by evolving the ability to exude compounds which downmodulate the host's inflammatory responses. There are an unknown number of these compounds, and at least two have been discovered. One is tuftsin-phosphorylcholine (TPC).
Hosts, including humans, have not evolved ways of ignoring these signaling molecules. Instead, our ancestors evolved _stronger_ inflammatory responses than are really needed, or healthy, to compensate for the ubiquitous down-modulation of such responses by one or more species of helminth. So without helminth infections, humans - with considerable individual genetic variation - are prone to having a stronger inflammatory response than is really healthy. This means that inflammation is often self-destructive. Sepsis is an obvious example. This kills 10 million people a year - and that was before COVID-19: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)32989-7/fulltext
Just over a century ago, we in developed nations got rid of our helminths. We did the same for our companion and agricultural animals as well - and probably also for our lab rats and other non-human animals used by researchers.
This is the primary reason for the vast swath of overly inflammatory illnesses, many of them auto-immune - triggered by (adaptive) immune responses to our own cells.
So far, no-one has made any of these compounds available as drugs to suppress excessive inflammation, but some people find it best to suppress their psoriasis, rheumatoid arthritis, Crohn's disease, life-threatening asthma by deliberately being infected by one of several relatively benign helminths. See https://helminthictherapywiki.org .
To make matters _much_ worse, most humans have only a 1/2 to 1/10th of the 50 ng/mL (125 nmol/L = 1 part in 20,000,000 by mass) circulating 25-hydroxyvitamin D their immune systems need to function properly. https://vitamindstopscovid.info/05-mds/
25-hydroxyvitamin D is an essential input (raw material, it is not a signaling molecule in itself) for immune cells (most types, as best we know, but also other types not related to the immune system) to run their internal (intracrine. also known as "autocrine") signaling system, which plays a major role in individual cells being able to change their behaviour in response to their changing circumstances. (Some of the signaling molecule - 1,25-dihydroxyvitamin D - can also diffuse from these cells and affect the behaviour of other cells nearby, typically of different types. This is paracrine signaling.) See: https://vitamindstopscovid.info/02-autocrine/ .
So most humans have the double-whammy of lack of helminths and grossly inadequate vitamin D3 intakes (UV-B on the skin can make it too, but this damages DNA and so causes skin cancer - and there is very little in food or multivitamins) with resultant immune system dysregulation and general dysfunction due to lousy circulating 25-hydroxyvitamin D levels.
Virtually no researchers - including vitamin D researchers - recognise the problems caused by lack of helminths. Some vitamin D researchers are on the case of excessive inflammation - see Chauss et al. 2021 on Th1 regulatory lymphocytes from the lungs of hospitalised COVID-19 patients: https://aminotheory.com/cv19/icu/#2021-Chauss. However not one of them AFAIK discuss lack of helminths. Lots of researchers into inflammatory disorders (dozens or hundreds of disorders) don't think about either vitamin D or lack of helminths. The few people researching helminths and inflammation don't seem to think about lousy 25-hydroxyvitamin D levels.
Please bear all this in mind when discussing inflammation in humans, experimental animals (probably low vitamin D, surely without helminths) and our companion and agricultural animals. (Indoor agricultural animals often get decent vitamin D3 intakes - this is what most manufactured vitamin D3 cholecalciferol is used for. They die or do not produce food properly if they are deficient.)
For reasons unknown, higher than 50 ng/mL 25-hydroxyvitamin D levels can suppress the excessive inflammation of psoriasis, MS, rheumatoid arthritis etc. See the research articles cited at: https://vitamindstopscovid.info/06-adv/ - including those on helminths.
If most people had helminths and proper vitamin D3 intakes, such as 0.125 mg 5000 IU a day for 70 kg bodyweight, there would be a lot less trouble with excessive inflammation. Then these so-called vaccines against SARS-CoV-2 would probably cause less trouble, in some respects at least.
Then, there would be little reason to bother with such quasi-vaccines because few people infected with SARS-CoV-2 would become seriously ill. Those infected would shed less viruses in general and so overall rates of transmission would be very much lower than today - probably to the point of the disease not spreading very much.
However, 5000 IU a day is a gram every 22 years, and pharma grade vitamin D3 costs USD$2.50 a gram, ex-factory - so where's the profit in that??
Hey Robin! I've been wondering where you've been and I'm glad to see you're OK. I've heard of the helminth hypothesis in relation to controlled immunity. It's really fascinating, especially considering we're at the point where we are examining the effects of bacteria and possibly viruses on our biological processes. It would be quite ironic if the push for Ivermectin may actually end up detrimental because of the effects on helminths, although I will also say I don't know much about the research.
Have you seen Brett and Heather's recent Darkhorse podcast where they discuss intracellular melatonin being made in near IR light? I thought it was fascinating and adds to the overall reason as to why we should be outside.
Look for Dr. Sabine Hazan's work on COVID and microbiome. She is talking about it a lot on Twitter.
Helminths a strategic actor within a diverse and healthy microbiome. I have read about this before. Big farming and the use of all sorts of chemicals would reduce healthy contact with microbiome on plants.
Vitamin D is a more complicated subject when looking at inflammation. It can be immunosupressive and reduce symptoms which may be great in treating leftover inflammation from a virus defeated, but can be problematic with chronic infections like the tickborne. The active form of vitamin D - 1,25 Dihydroxyvitamin D can be present in high quantities while the inactive reservoir is low during an infection. At key points you don't want to be dousing the system with more exogenous D. This timing awareness of monitoring and using or not using D is important to understand in managing more chronic infections.
You might find the work of Dr. Amy Proal on her website Microbe Minded: https://microbeminded.com/
Proal wrote one the more amazing and beautifully papers I have read in my career: Immunostimulation in the Era of the Microbiome, in 2011.
This and her other papers are listed here:
https://microbeminded.com/my-research/
I've read about that when doing my first look into Vitamin D. The research appears highly conflicting since it depends upon the type of precursor molecule, the bioavailability of exogenous Vitamin D, which cells take up which forms, which form gets used by cells and used during an infection, and which form is checked when looking for Vitamin D levels. Honestly, it all gave me a bit of a headache!
Hi Betsy, I read some of this work - Albert, Proal and Marshall's 2009 "Vitamin D: the alternative hypothesis" a few years ago. It makes no sense to me. I don't have time to write a critique and this is not the place for it, but I know of no vitamin D researchers who refer to this and related work.
Good supplies of 25-hydroxyvitamin D are needed so immune cells can run their intreacellular (intracine) and to nearby cells (paracrine) signaling systems properly. They need to do this in order to respond to their changing circumstances. This is unrelated to hormonal 1,25-dihydroxyvitamin D. Please see: What every MD, immunologist, virologist and epidemiologist should know about vitamin D and the immune system https://vitamindstopscovid.info/05-mds/ .
I understand that literature is large and complex. This is an alternative way of understanding and accommodating the same data. Vitamin D can act like a steroid and be helpful and also prevents and intervenes in many problems. But there is a vitamin D reversal condition that can happen in inflammatory disease. It happened to me and it is well known by good rheumatologists. Addressing elevated levels of 1,25 dihydroxycholecalciferol vitamin D (calcitriol) which can be inflammatory until one gets well does work almost miraculously if that reversal is part of the problem. It is important when advising everyone to dose up on more and more Vitamin D to understand that some additional testing for the active form and confirming that there isn't a reversal syndrome going on would be important to understand in people who are sick. When one has too much calcitriol (the body's defense being activated against a pathogen) it seems to know to lower the pool of inactive D, the stuff we take in the supplements. It seems that is a natural balancing act that we need to be careful not to disrupt at specific time frames in an illness. But Dr. Proal is really the expert on this topic.
I am still surprised that there is no widespread discussion of vaccine LNPs in the context of CARPA or complement activated pseudoallergy. LNPs have been around as vehicle in pharmaceuticals. CARPA doesn't respond to an EpiPen. Far more inflammatory and long lasting. I knew this was something that precluded my getting this particular product from the moment I heard that the mRNA was encapsulated by LNPs. It is part of the story of the toxicity of the vaccines.
LNPs and complement reactions also an issue in nanomedicines. Contrast media. Infused ABs.
https://pubmed.ncbi.nlm.nih.gov/31275462/
https://pubmed.ncbi.nlm.nih.gov/31544866/
I haven't heard of CARPA before, so thanks for pointing me to that. I'll see if I can find additional articles. There was a lot of talk about PEG being immunogenic, but I am not sure how extensive the anti-PEG response is, or what the effects are really. It'd be pretty interesting if the vaccines had reduced efficacy because of the prevalence of anti-PEG antibodies in the population.
Yes there are dozens of papers on CARPA and the toxicity and immumogencity of nanolipids and nanomedicines. in PubMed and check ResearchGate. I knew something was wrong when everyone kept talking about anaphylaxis and not CARPA. Treatments are different, CARPA more difficult to manage. The media talked about this as something simple handled with an Epi-Pen as if even anaphylaxis was trivial. If this is your area someone should write a paper on this being unrecognized--and I think on purpose.
I saw a paper or two, which seems very interesting. I'll try looking into it further later on.
So, I didn't take the time to read the stuffy, but collating what you've d said with other readings, andfree floating mind at work. We know the LPNs she'd from the jabbed population. Some of the LPNs have reassembled, contain mRNA, and then transfer in the environment to me, or you, or....
So the future of self replicating "vaccines" is at hand.
Well I'm not quite sure the LNPs are being shed, but I've heard people mention spike protein shedding although I don't find much evidence of it occurring aside from anecdotal evidence. It also may be rather difficult to wrap up the mRNA again and release them to wreak some more havoc. I think there may be a few steps to being able to release LNPs in the air.
This was what was knocking around in my head when I wrote, a post by Igor Chidov from last week about LNPs being shed https://igorchudov.substack.com/p/vaccine-shedding-finally-proven?r=qvwy9&s=r&utm_campaign=post&utm_medium=web&utm_source=direct
It references Ig
From his article:
It turned out that vaxxed parents actively shed vaccine-produced particles onto their children so that the kids acquired “humoral immunity” following shedding from their parents! Not only was this finding evident in the data, it actually was STRONGLY statistically significant with p-value of 0.01! This means that this was not a chance finding.
I saw that post, but the study was very small and did not elaborate too much. One experiment took masks from lab employees and checked for antibodies. Then they took nasal swabs in households and checked family members. The big issue is that we don't know the status of the people within that household and if they were sick prior to vaccination or not. We just know their status at the time, and the researchers just mention "SARS-COV2 antibodies", what antibodies to what antigens? I'm not sure, but if it was only anti-spike then maybe we can make an assumption.
We also don't know "what" is being shed. The researchers assume it's antibodies, Igor assumes it's the spike, and I think the study isn't well-controlled enough to discern anything.
I think it's an interesting starting point, but I would need to see more evidence before making any assumptions.
I'm still weak on endosomes, but it seems to me that there's some paradox that ensures that ionizable lipids can't be toxic since they are only positive if in an endosome. So even though thy fuse with the endosome via acquiring the positive charge in the endosome, they can't "escape" it without losing charge, even if somehow they keep being cycled back into more endosomes or other membranes. Trippy.
Wait, I got the pKa thing wrong, a lower pKa would make it more acidic! Disregard that point 😅
I'm still trying to figure this out, since this behavior will be akin to fluvoxamine or chloroquine derivatives and their lysosomotropic behavior. Typical amines have a pKa around 9 so they should be protonated at physiological pH. However, these tertiary amines may actually have a pKa near 7, possibly due to donation of electron density through the sigma bonds of the carbon chains conferring greater stability of cation formation.
If that's the case then they are likely to be neutral at physiological pH, enter into endosomes, become positively charged, and I suppose charge repulsion may cause the lipids to break apart and release the mRNA?
Which begs the question as to why they may interact with membranes in the first place if they aren't fully cationic in nature. There are a few quaternary lipids in the formulation, so I suppose there's that as well as something called the zeta potential at play that may cause them to favor membrane fusion. Honestly, this field of research appears to still be in its early stages and so many things haven't quite been sorted out yet.
The sponging effect interesting. Some writers, I recall, who specialize in obesity and metabolic disorders, saw the deposits of fats in unusual areas as ways of sequestering dangerous amounts of lipids in places that will protect the person from their existence.
I mentioned it more for some inquiry since it may be something rather interesting. I've seen several people bring up this idea before so it's probably been around for quite some time. It would actually be paradoxical if obese people were more protected from adverse vaccine reactions while healthy people would be better protected against the infection.
And what if the vaccines cause further obesity or lipodystrophy in further attempt at sequestration of toxin?
Well, I don't have any knowledge on this topic since I'm just providing a rather superficial hypothesis, but do you have any insight into this possibility? The main factor would be the degradation of the ionizable lipids, but acid-based ester hydrolysis is rather difficult and I am unaware of regions in the body that are highly basic. The liver should be able to hydrolyze the ester links, and if that's a big concern it may be worth considering utilizing the "first pass effect" to get the lipids to degrade quickly.