Very much looking forward to your next post comparing L-cysteine, NAC, and glutathione, in particular for healthy individuals that were vaxxed and then experienced mild to severe covid vaccine adverse effects (e.g, irregular heart rate). Some thought on supplementing a omnivore diet vs. vegan/vegetarian diet might also be of use, as well as answering whether this should be a daily supplement or whether it should be temporarily taken until any adverse effects appear to have stopped. The question of the future availability/accessibility of these products might also be an interesting factor to address too. Other supplements of interest are PQQ and DMG. How these relate to glutathione-related supplements or other considerations of use would also be appreciated.
I’ve been supplementing with NAC and Glutathione for a couple years. I think it’s a real big boost for one’s immune system. When I heard a few doctors (alternative media of course) recommend these supplements among many, I thought it can’t hurt. I think it helps immensely with the healing process of your body! I just had a cancerous uterine tumor removed (in hospital for 3 days), cancer gone and I healed well! Praise God!
Seems like NAC was being used effective in aiding respiratory symptoms with covid? That was why the FDA suddenly looked at declaring it a drug and not supplement.
Not a study, but references to studies here:
“Clinical studies have shown that NAC can help treat or prevent worsening of chronic bronchitis and acute respiratory distress syndrome, an often fatal complication in patients with pneumonia or other severe lung infections.7-12
In patients with chronic obstructive pulmonary disease (COPD), N-acetyl-L-cysteine has been associated with lower rates of exacerbations (periods of worsening of symptoms) and fewer days spent in the hospital.4,13-18”
Aug 17, 2022·edited Aug 17, 2022Liked by Modern Discontent
Thank you for these informative articles! This is a very important topic, especially to those of us who are taking these supplements regularly and to those they might help.
Considering adsorption, NAC seems advantageous in that NAC will not compete with amino acid transporter uptake of dietary L-cysteine. I suspect that the gut adsorption and transport of Glutathione is limited, and it is primarily broken down into its component amino acids. A few minutes looking at CACO-2 glutathione adsorption did not find any useful results.
Thank you for this review. Another function of NAC has been to thin mucosal secretions. This can be helpful when dealing with a full chest and phlegm. The therapeutic dose seems to be at least 1.8-2.2 grams to see a significant effect. Dosing of 600mg in previous papers showed no statistical difference, but this was not being measured for long-term use.
As for the loading dose, this was not often used because NAC has a 6-hour half-life. This is helpful to know in treatment. Q4. Taking NAC while actively sick every 6-8 hours- up until ARDS.
I appreciate the attention to detail with GSH vs NAC. GSH has been shown to be helpful when nebulized in saline at times of significant respiratory distress. I can find links to these other articles if there is further interest. And yes, GSH is largely disposed of in the body when taken as a supplement, this is why its precursor, NAC, is so important.
Very much looking forward to your next post comparing L-cysteine, NAC, and glutathione, in particular for healthy individuals that were vaxxed and then experienced mild to severe covid vaccine adverse effects (e.g, irregular heart rate). Some thought on supplementing a omnivore diet vs. vegan/vegetarian diet might also be of use, as well as answering whether this should be a daily supplement or whether it should be temporarily taken until any adverse effects appear to have stopped. The question of the future availability/accessibility of these products might also be an interesting factor to address too. Other supplements of interest are PQQ and DMG. How these relate to glutathione-related supplements or other considerations of use would also be appreciated.
I’ve been supplementing with NAC and Glutathione for a couple years. I think it’s a real big boost for one’s immune system. When I heard a few doctors (alternative media of course) recommend these supplements among many, I thought it can’t hurt. I think it helps immensely with the healing process of your body! I just had a cancerous uterine tumor removed (in hospital for 3 days), cancer gone and I healed well! Praise God!
Apparently the body makes more natural glutathione with NAC (+ glycine) rather than using glutathione supplements that mostly pass through the body.
Seems like NAC was being used effective in aiding respiratory symptoms with covid? That was why the FDA suddenly looked at declaring it a drug and not supplement.
Not a study, but references to studies here:
“Clinical studies have shown that NAC can help treat or prevent worsening of chronic bronchitis and acute respiratory distress syndrome, an often fatal complication in patients with pneumonia or other severe lung infections.7-12
In patients with chronic obstructive pulmonary disease (COPD), N-acetyl-L-cysteine has been associated with lower rates of exacerbations (periods of worsening of symptoms) and fewer days spent in the hospital.4,13-18”
https://www.lifeextension.com/magazine/2020/ss/protect-your-respiratory-system
Thank you for these informative articles! This is a very important topic, especially to those of us who are taking these supplements regularly and to those they might help.
Considering adsorption, NAC seems advantageous in that NAC will not compete with amino acid transporter uptake of dietary L-cysteine. I suspect that the gut adsorption and transport of Glutathione is limited, and it is primarily broken down into its component amino acids. A few minutes looking at CACO-2 glutathione adsorption did not find any useful results.
Thank you for this review. Another function of NAC has been to thin mucosal secretions. This can be helpful when dealing with a full chest and phlegm. The therapeutic dose seems to be at least 1.8-2.2 grams to see a significant effect. Dosing of 600mg in previous papers showed no statistical difference, but this was not being measured for long-term use.
As for the loading dose, this was not often used because NAC has a 6-hour half-life. This is helpful to know in treatment. Q4. Taking NAC while actively sick every 6-8 hours- up until ARDS.
I appreciate the attention to detail with GSH vs NAC. GSH has been shown to be helpful when nebulized in saline at times of significant respiratory distress. I can find links to these other articles if there is further interest. And yes, GSH is largely disposed of in the body when taken as a supplement, this is why its precursor, NAC, is so important.
NACIS study (acronym for N-acetylcysteine in Immune System)???????????
isn't there a better name out there??? That really smells like deliberate mutilation of a NATURAL way of healing....