A study provides a possible mechanism of gut translocation and bacteremia in SARS-COV2 patients, however with some serious limitations and possible alternative explanations.
"However, given that nearly all patients were prescribed antibiotics upon admission to hospitals for COVID" this is my impression as well, but do you have a source for how often antibiotics were actually used?
That antibiotics were withheld has become a new conspiracy theory thanks to jikky/arkmedic https://arkmedic.substack.com/i/79557186/what-does-matter-then But I see several studies reporting high use for hospitalized patients in discrete settings so I think the conspiracy theory is a whiff.
Several of the articles I've looked at have noted antibiotic use, usually with some comment about how discretion should be used. I believe it's rather common that antibiotics such as azithromycin were part of the original protocol, and generally I believe it's part of the protocol for any ICU patients.
In this CDC document they comment on page 9 that up to 80% of hospitalized patients early on were given antibiotics, but their reference is to a review of regression models, so I'm not sure what to make of that.
"From March 2020 to October 2020, almost 80% of patients hospitalized with COVID-19 received an antibiotic.13
Antibiotic use was lower overall as of August 2021 compared to 2019 but increased for some antibiotics like azithromycin and ceftriaxone. Approximately half of hospitalized patients received ceftriaxone, which was commonly prescribed with azithromycin.
This likely reflects difficulties in distinguishing COVID-19 from community-acquired pneumonia when patients first arrive at a hospital for assessment."
There was one article which even made a comment about how high use of the chloroquine analogues may have contributed, but it's within all of my other studies so I'd have to look and find specific studies.
Are jikky/arkmedic the same person? Jikky was the person who noted that "negative efficacy" study while commenting on ADE, and I believe arkmedic was commenting on IgG4 but noted that tweet, which didn't really make sense to me.
Is this part of the idea that all of this was actually due to a bacterial infection and not a virus? Not to suggest that jikky or arkmedic are making that argument but I can see that being something that is now being propped up by a few people.
Not sure what's happening right now with everything going on to be honest...
I always forget if they are the same, but I think so. Anyway no, the claim is that people die of secondary infections that should have been prevented with antibiotics. So now it's become "cannon" that no one was given antibiotics, which appears to be totally false. Appreciate the link very much, I'll credit that if I do a post.
Interesting. That would go counter to my point as my point was that the interventions would inherently lead to possible infection with antibiotic-resistant bacteria with long stay, medical interventions, and indiscriminate antibiotic use being the driving forces. This was part of what I was alluding to but will probably piece together in another post.
So my perspective would be that rampant antibiotic use would have inherent downsides, while the opposing narrative would argue that lack of antibiotic use would be the issue it appears.
In any case, it's strange how short of a memory people have. I remember when the original hospital protocols were released that antibiotics were part of the protocol, but even if in only select cases I believe it's just common practice for hospitals to prescribe antibiotics especially for ICU patients, hence the problem with nosocomial infections with antibiotic-resistant strains.
No problem! I sort of wish I included that in my article now but I didn't look to find an actual statistic given that most studies cite antibiotic use so it seemed like it was just common practice. 🤷♂️
Also, is it "canon?" rather than "cannon"? But this is coming from someone with his own issues with grammar!
A weak gut barrier Seems to be the common explanation among alternative health practitioners (checkout the healthmeans summits) for many ailments. healing the gut seems to be highly recommended as a source of health. Intermittent fasting allows healing time. the lining can get microscopic tears (leaky) from exposure to food containing the chelator-glyphosate, toxins such as toxic proteins, metals and undigested stuff and of course medications.
It's certainly making it's way into mainstream medicine as well. Many maladies can be tied to inflammation, and so it's not a surprise that systemic inflammation may alter the gut microbiome and make it more permeable. One of the issues with many of these other maladies becomes a case of "chicken or the egg". For instance, does obesity cause the gut dysbiosis, or is it the poor eating habits that alters the gut to then make one more susceptible to obesity? Or is it both, and at some point the eating becomes secondary as the obesity and gut dysbiosis becomes a recursive feedback that self perpetuates?
What's interesting is that there's an argument to be made that fasting may be one of the problems during an infection. It may certainly help during times when the body is normal or not fighting a pathogen, but when someone is sick they may be depriving the body of vital nutrients.
My next write-up will focus on the hospital's role in these diseases, but it's worth remembering many of these gut bacteria thrive on things such as dietary fiber, and so someone who is intubated or not given whole foods will inherently have their gut microbiome alter as well. But that sort of begs the question of how one gets fiber into an intubated patient, and what factor prolonged stay within a hospital does to the gut by depriving it of nutrients.
That's a bit of a tangent, but there's tons to consider with the microbiome! The glyphosate is interesting. Many external toxins would have to be balanced with nutritional agents, and so figuring out that balancing act would be key to maintaining the gut.
Yes malnutrition can result from gut dysfunction. Glyphosate is present in all foods even I am told organic. Glyphosate is used to dessicate grains to make harvesting convenient. This purpose was never originally intended. They keep raising the allowable glyphosare limits. While glyphosate toxicity may be said to be low on human cells it was not tested on human microbiome. Same for medications effects on human microbiome.
Sure, but the intent of this post and my Substack in general is to provide my perspective, which is to examine a study or a topic and provide additional context to inform and educate readers. I look at what's going on, I try to parse the information and see if there are explanations or paths worth examining.
I try not to let my biases enter my work, but everyone has their own biases. From my perspective viruses can be pathogenic, but people are free to argue otherwise. Because of that my coverage comes from that perspective although I am contextualizing it, as I have tried to do when considering secondary bacterial infections.
Other people are going to have a different perspective, and may take the position to argue that all of this is not related to viruses, and that's for them to do, but this is my own perspective on the matter and so my writings reflect that.
"However, given that nearly all patients were prescribed antibiotics upon admission to hospitals for COVID" this is my impression as well, but do you have a source for how often antibiotics were actually used?
That antibiotics were withheld has become a new conspiracy theory thanks to jikky/arkmedic https://arkmedic.substack.com/i/79557186/what-does-matter-then But I see several studies reporting high use for hospitalized patients in discrete settings so I think the conspiracy theory is a whiff.
Several of the articles I've looked at have noted antibiotic use, usually with some comment about how discretion should be used. I believe it's rather common that antibiotics such as azithromycin were part of the original protocol, and generally I believe it's part of the protocol for any ICU patients.
In this CDC document they comment on page 9 that up to 80% of hospitalized patients early on were given antibiotics, but their reference is to a review of regression models, so I'm not sure what to make of that.
https://www.cdc.gov/drugresistance/pdf/covid19-impact-report-508.pdf
"From March 2020 to October 2020, almost 80% of patients hospitalized with COVID-19 received an antibiotic.13
Antibiotic use was lower overall as of August 2021 compared to 2019 but increased for some antibiotics like azithromycin and ceftriaxone. Approximately half of hospitalized patients received ceftriaxone, which was commonly prescribed with azithromycin.
This likely reflects difficulties in distinguishing COVID-19 from community-acquired pneumonia when patients first arrive at a hospital for assessment."
There was one article which even made a comment about how high use of the chloroquine analogues may have contributed, but it's within all of my other studies so I'd have to look and find specific studies.
Are jikky/arkmedic the same person? Jikky was the person who noted that "negative efficacy" study while commenting on ADE, and I believe arkmedic was commenting on IgG4 but noted that tweet, which didn't really make sense to me.
Is this part of the idea that all of this was actually due to a bacterial infection and not a virus? Not to suggest that jikky or arkmedic are making that argument but I can see that being something that is now being propped up by a few people.
Not sure what's happening right now with everything going on to be honest...
I always forget if they are the same, but I think so. Anyway no, the claim is that people die of secondary infections that should have been prevented with antibiotics. So now it's become "cannon" that no one was given antibiotics, which appears to be totally false. Appreciate the link very much, I'll credit that if I do a post.
Interesting. That would go counter to my point as my point was that the interventions would inherently lead to possible infection with antibiotic-resistant bacteria with long stay, medical interventions, and indiscriminate antibiotic use being the driving forces. This was part of what I was alluding to but will probably piece together in another post.
So my perspective would be that rampant antibiotic use would have inherent downsides, while the opposing narrative would argue that lack of antibiotic use would be the issue it appears.
In any case, it's strange how short of a memory people have. I remember when the original hospital protocols were released that antibiotics were part of the protocol, but even if in only select cases I believe it's just common practice for hospitals to prescribe antibiotics especially for ICU patients, hence the problem with nosocomial infections with antibiotic-resistant strains.
No problem! I sort of wish I included that in my article now but I didn't look to find an actual statistic given that most studies cite antibiotic use so it seemed like it was just common practice. 🤷♂️
Also, is it "canon?" rather than "cannon"? But this is coming from someone with his own issues with grammar!
The source for the remarks on that presentation:
% of "Covid-19" inpatients with antibiotics
https://academic.oup.com/ofid/article/8/6/ofab236/6291836
-716 hospitals and 213k inpatients, that's a big improvement on my handful of examples
Trends in hospital / other setting use
https://emergency.cdc.gov/coca/ppt/2021/111821_slide.pdf
Wow, very interesting finds!
It's canon. All bets are off in these tiny substack comments anyway, I can't ever even see what I am typing.
Yeah, there's plenty of times I use "it's" instead of "its". I wonder if it's reflexive for me to type certain words out when I intend not to.
A weak gut barrier Seems to be the common explanation among alternative health practitioners (checkout the healthmeans summits) for many ailments. healing the gut seems to be highly recommended as a source of health. Intermittent fasting allows healing time. the lining can get microscopic tears (leaky) from exposure to food containing the chelator-glyphosate, toxins such as toxic proteins, metals and undigested stuff and of course medications.
It's certainly making it's way into mainstream medicine as well. Many maladies can be tied to inflammation, and so it's not a surprise that systemic inflammation may alter the gut microbiome and make it more permeable. One of the issues with many of these other maladies becomes a case of "chicken or the egg". For instance, does obesity cause the gut dysbiosis, or is it the poor eating habits that alters the gut to then make one more susceptible to obesity? Or is it both, and at some point the eating becomes secondary as the obesity and gut dysbiosis becomes a recursive feedback that self perpetuates?
What's interesting is that there's an argument to be made that fasting may be one of the problems during an infection. It may certainly help during times when the body is normal or not fighting a pathogen, but when someone is sick they may be depriving the body of vital nutrients.
My next write-up will focus on the hospital's role in these diseases, but it's worth remembering many of these gut bacteria thrive on things such as dietary fiber, and so someone who is intubated or not given whole foods will inherently have their gut microbiome alter as well. But that sort of begs the question of how one gets fiber into an intubated patient, and what factor prolonged stay within a hospital does to the gut by depriving it of nutrients.
That's a bit of a tangent, but there's tons to consider with the microbiome! The glyphosate is interesting. Many external toxins would have to be balanced with nutritional agents, and so figuring out that balancing act would be key to maintaining the gut.
Yes malnutrition can result from gut dysfunction. Glyphosate is present in all foods even I am told organic. Glyphosate is used to dessicate grains to make harvesting convenient. This purpose was never originally intended. They keep raising the allowable glyphosare limits. While glyphosate toxicity may be said to be low on human cells it was not tested on human microbiome. Same for medications effects on human microbiome.
At least the study can make people aware of the importance of a healthy gut biome.
There really is a lot that goes on with the microbiome that shouldn't be underestimated, but not much may be done to attempt to improve it. 🤷♂️
I still think it's a mistake assuming all of this is caused by a virus.
Sure, but the intent of this post and my Substack in general is to provide my perspective, which is to examine a study or a topic and provide additional context to inform and educate readers. I look at what's going on, I try to parse the information and see if there are explanations or paths worth examining.
I try not to let my biases enter my work, but everyone has their own biases. From my perspective viruses can be pathogenic, but people are free to argue otherwise. Because of that my coverage comes from that perspective although I am contextualizing it, as I have tried to do when considering secondary bacterial infections.
Other people are going to have a different perspective, and may take the position to argue that all of this is not related to viruses, and that's for them to do, but this is my own perspective on the matter and so my writings reflect that.