This is an important part of the Covid-19 puzzle, that affects long haulers, who are stuck with a bewildering array of somewhat conflicting symptoms, from loss of smell an taste, tinnitus, headache, vascular and endothelial impairments, fatigue, cachexia, loss of appetite, weight, and dysbiosis. How are they all connected? Stress!
Dr. Bruce Patterson found monocytes infected with Sars-Cov-2 or it’s proteins. Dr.Juan Mauricio and his team found that “sun-threshold stress was enough to recruit monocytes from the spleen to the brain, where they shape-shift in macrophages that toggle M1 anti inflammation with fractalkine and M2 inflammation. With fibrin. If these macrophages are infected they will release fibrin and fractalkine which is a neurotoxin and adhesion molecule that explains headaches and loss of memory and taste, and it also explains why blood thinners do not break up blood clots. Here’s the thing, our guts do the same thing as M1:M2 macrophages in controlling inflammation of our microbiome. Ask yourself, how do bats have Ebola. Coronavirus and rabies in their microbiome? Then ask yourself how do bats live the longest of all mammals for their size, 230 human years and hardly any cancer? GI hormesis. Remember the king who defied the Romans by ingesting poison to prevent being poisoned? Well that is what your gut does. If invaded by a virus, it will produce inflammatory Th17 cells, but these will be matched by twice as many anti inflammatory T-Reg cells, so long as you have enough segmented filamentous bacteria like B. Fragilis that we no longer have. Liminal stress, below the level of awareness is controlled from the thalamus for speed of reaction to infection, which is a good this, but if macrophages are infected and disseminated all over the body, and we have few commensals, is gut diversity to offset disease, the we are in trouble. Dr. Bruce Patterson of the Covid Chronic care, uses statins to block fractalkine and antivirals to attack the viral reservoirs, buts it’s up to us to control stress inside of us and social stress of out industrial society, and crest biodiversity so our children can have a Noah’s Arc microbiome.
I remember Dr. Patterson and I believe Dr. Yoh released a study noting spike was retained within monocytes, and they argued that the spike retainment was one of the reasons for the endothelial inflammation and damage. To that, they tried using a CCR5 antagonist to prevent monocytes from binding to endothelial lining of blood vessels I believe.
The more I look into it the more significant it is to consider our bodies as dynamic reservoirs all attempting some form of maintenance. Bacteria keep us in check, we keep bacteria in check, we used to have parasites like helminths that we kept in check, but also may have kept bacteria in check. More is being learned about the virome which would keep all 3 in check and us the same.
It's all a balancing act, and each addition is like adding a puzzle piece that prongs off into 3 other directions that need more connections. I think this adds more to the fact that lockdowns may have limited a ton of microbe movement and that likely was very damaging to us.
Wow! This is great information. Thank you, but the problem is even worse. Our biome has the same ability for T-cells to toggle between inflammatory Th17 cells provoked by viruses and anti inflammatory T-reg cells, but this requires segmented filamentous bacteria like B. Fragilis that we no longer have in our gut. Consider the bat which has Ebola, Corona, Rabies viruses in their biomes, which provokes Th17 antibodies and because the bat has plenty of SFB it produces twice as much T-Regs to control the inflammation. It is called GI hormesis which converts pathogens into commensals like water into wine. We can no longer do that and are less resilient. Can you see the delicious irony? We are now reliant on bars to eat mosquitoes and ticks migrating north because of climate change. We need to increase biodiversity in order for our kids to get Noah’s Arc biomes like the bat to increase resilience and anti- fragility, like the Tsimane tribe in the Bolivian Amazon rain forest, who have perfect blood pressure and very little dementia from worms in their biomes. Check out The Tsimane study in the Lancet. Keep up the good work. I have a book coming out in March called Pandoras Box that explains all of this.
Some of these studies have noted B. Fragilis within the gut. I believe the review on Bacteroides actually spends a lot of time detailing B. Fragilis as a possible pathogen.
However, I wouldn't be surprised if our microbiome has lost many of the species that were passed down for many generations.
I tried thinking of an analogy for this, but I think about it within the context of baker's yeast, in which bakers may have a giant batch of yeast which they pass down through the generations and are used to make decades of baked goods.
It makes me wonder how much of our microbiome, passed down through decades and centuries, were just completely washed away via antibiotics and the era of incessant sterility.
It's definitely worth considering ways to strengthen the gut and microbiome rather than trying to just rid ourselves of some of these bacteria. I think it's one of the biggest issues hospitals are facing.
Interesting, I'll try to be on the lookout for the book! I've been so behind in my reading but I'll try to take a gander when it comes out!
Fascinating article, we love the poop collecting efforts by public health researcher Abdifatah Muhummed, collecting stool samples from children in a remote, pastoralist community in Ethiopia’s Somali Region. We believe the collection and study of fresh poop samples is essential to unlocking the secrets of the microbiome and the medicine of tomorrow.
A Mass Extinction Is Taking Place in the Human Gut
To preserve humankind’s diverse bacteria, scientists are harvesting, freezing, and storing poop from around the world.
I have read through this interesting review and although the sole focus is not on SARS-CoV-2 infection there are some interesting concepts discussed in relation to the human lung microbiome and disease.
The authors conclude that there is a bi-directional relationship between microbial ecosystems and host susceptibility to infectious and other diseases.
1) Microbiomes may serve as the source of infection-causing pathogens
2) Invading pathogens have the ability to alter the host's microbial communities for extended periods of time.
Also discussed are the environmental insults that predispose not only hosts' tissues but also human microbiota to the disease development by changing microbial composition, host immunity, and epithelial integrity.
What was really interesting to me as a promoter of simple yet effective interventions is that there is mention of replenishing and promoting certain species from exposure to rich and healthy ambient air microbiomes (e.g. forest microbiome).
These are important concepts to consider when trying to understand the relationship between our environmental inputs, our microbiome interactions and health.
Human airway and lung microbiome at the crossroad of health and disease
In lieu of the "virus causing gut dysbiosis" information I was actually curious whether SARS-COV2 in the gut was a consequence of viral persistence or of prolonged dysbiosis. A few of the studies looking at viral persistence usually rely on PCR or presence of spike antigen which is interesting, but they don't provide us any information on the viability of the virus. One year would be really interesting because without routine follow-up you run into the issue of repeat infections or other variables muddying the assessment of that information.
I would lean more towards the idea that viral persistence may occur but the dynamics may likely be dependent upon the microenvironment, in that it's possible that those who already have altered gut microbiomes may be more susceptible to persistence due to the inability to properly produce barriers against viruses.
Thanks for the link! I mentioned something like that one of my other microbiome posts one reader left a comment about the Strep A rise, and I built off of the idea that masking would have inherently blocked bacteria but not viruses, and therefore the constant masking, especially outdoors, likely prevented enrichment from environmental microbes or the exchange of beneficial microbes between people, and this may be related to much of what's going on right now.
Like with all other comorbidities, dysbiosis should probably be considered its own comorbidity.
"If you are NOT VACCINATED for COVID-19 and you have NEVER TESTED POSITIVE for the virus, please consider donating your stool for research. "
I'm guessing she wants to scour feces to see why some people just don't get sick? That'd be an interesting place to look given the context of my current posts!
18 months some people still have viral reservoir far as I remember. If you look for Carlo Brogna on twitter, LinkedIn, Facebook etc he has just published a new study to add to his collection.
“the toxins produced by our bacteria (gut) can be when they replicate the SARS-CoV-2 virus; we show the data on vitro use of antibiotics to contrast not only the repl Viral ication in bacteria but also their toxicological production.”
If you look on twitter for “Vedicinals9 India Pvt Ltd” they do videos
“Comprehensive analysis of Covid and Long Covid driving mechanisms and Protocols for the management of these severe multisystemic condition”
However, the title is mixing a few things together. In reading it apparently the patient reached a point during the first infection in which he began testing negative but his fecal samples were still testing positive. The length of time for positivity doesn't seem clear. They mention the nasopharyngeal testing appeared negative on day 10 so we can assume that the fecal tests maybe extended past that.
However, the 18 months is in reference to a reinfection with Omicron. The "Previous Case with Multiple Negative Nasopharyngeal Swab Tests and Positive Fecal Molecular Test" refers to the first infection, then the reinfection occurred 18 months out.
He apparently had this article which seems interesting:
I haven't read through it so I'm not sure what it includes but it'd be an interesting perspective to consider SARS-COV2 being a possible bacteriophage.
Thanks for the Twitter link as well. It appears he posts a lot of articles so it may be a good place to see what studies are out there.
There is more people at 18 months. You can test negative but actually be positive, Gustavo also comments on that and puts another one of his studies of a different test. It’s intracellular something like that. Also people shed it in poo one study it was shedding for a year. Oral fecal transmission has been known for a long time apparently there are many studies on it.
This is an important part of the Covid-19 puzzle, that affects long haulers, who are stuck with a bewildering array of somewhat conflicting symptoms, from loss of smell an taste, tinnitus, headache, vascular and endothelial impairments, fatigue, cachexia, loss of appetite, weight, and dysbiosis. How are they all connected? Stress!
Dr. Bruce Patterson found monocytes infected with Sars-Cov-2 or it’s proteins. Dr.Juan Mauricio and his team found that “sun-threshold stress was enough to recruit monocytes from the spleen to the brain, where they shape-shift in macrophages that toggle M1 anti inflammation with fractalkine and M2 inflammation. With fibrin. If these macrophages are infected they will release fibrin and fractalkine which is a neurotoxin and adhesion molecule that explains headaches and loss of memory and taste, and it also explains why blood thinners do not break up blood clots. Here’s the thing, our guts do the same thing as M1:M2 macrophages in controlling inflammation of our microbiome. Ask yourself, how do bats have Ebola. Coronavirus and rabies in their microbiome? Then ask yourself how do bats live the longest of all mammals for their size, 230 human years and hardly any cancer? GI hormesis. Remember the king who defied the Romans by ingesting poison to prevent being poisoned? Well that is what your gut does. If invaded by a virus, it will produce inflammatory Th17 cells, but these will be matched by twice as many anti inflammatory T-Reg cells, so long as you have enough segmented filamentous bacteria like B. Fragilis that we no longer have. Liminal stress, below the level of awareness is controlled from the thalamus for speed of reaction to infection, which is a good this, but if macrophages are infected and disseminated all over the body, and we have few commensals, is gut diversity to offset disease, the we are in trouble. Dr. Bruce Patterson of the Covid Chronic care, uses statins to block fractalkine and antivirals to attack the viral reservoirs, buts it’s up to us to control stress inside of us and social stress of out industrial society, and crest biodiversity so our children can have a Noah’s Arc microbiome.
I remember Dr. Patterson and I believe Dr. Yoh released a study noting spike was retained within monocytes, and they argued that the spike retainment was one of the reasons for the endothelial inflammation and damage. To that, they tried using a CCR5 antagonist to prevent monocytes from binding to endothelial lining of blood vessels I believe.
The more I look into it the more significant it is to consider our bodies as dynamic reservoirs all attempting some form of maintenance. Bacteria keep us in check, we keep bacteria in check, we used to have parasites like helminths that we kept in check, but also may have kept bacteria in check. More is being learned about the virome which would keep all 3 in check and us the same.
It's all a balancing act, and each addition is like adding a puzzle piece that prongs off into 3 other directions that need more connections. I think this adds more to the fact that lockdowns may have limited a ton of microbe movement and that likely was very damaging to us.
Wow! This is great information. Thank you, but the problem is even worse. Our biome has the same ability for T-cells to toggle between inflammatory Th17 cells provoked by viruses and anti inflammatory T-reg cells, but this requires segmented filamentous bacteria like B. Fragilis that we no longer have in our gut. Consider the bat which has Ebola, Corona, Rabies viruses in their biomes, which provokes Th17 antibodies and because the bat has plenty of SFB it produces twice as much T-Regs to control the inflammation. It is called GI hormesis which converts pathogens into commensals like water into wine. We can no longer do that and are less resilient. Can you see the delicious irony? We are now reliant on bars to eat mosquitoes and ticks migrating north because of climate change. We need to increase biodiversity in order for our kids to get Noah’s Arc biomes like the bat to increase resilience and anti- fragility, like the Tsimane tribe in the Bolivian Amazon rain forest, who have perfect blood pressure and very little dementia from worms in their biomes. Check out The Tsimane study in the Lancet. Keep up the good work. I have a book coming out in March called Pandoras Box that explains all of this.
Some of these studies have noted B. Fragilis within the gut. I believe the review on Bacteroides actually spends a lot of time detailing B. Fragilis as a possible pathogen.
However, I wouldn't be surprised if our microbiome has lost many of the species that were passed down for many generations.
I tried thinking of an analogy for this, but I think about it within the context of baker's yeast, in which bakers may have a giant batch of yeast which they pass down through the generations and are used to make decades of baked goods.
It makes me wonder how much of our microbiome, passed down through decades and centuries, were just completely washed away via antibiotics and the era of incessant sterility.
It's definitely worth considering ways to strengthen the gut and microbiome rather than trying to just rid ourselves of some of these bacteria. I think it's one of the biggest issues hospitals are facing.
Interesting, I'll try to be on the lookout for the book! I've been so behind in my reading but I'll try to take a gander when it comes out!
GSE grapefruit seed extract is a good antibiotic anti fungal antibacterial, anti yeast. Many uses. Use Citricidal by Higher Nature or NutriBiotic.
Just saw this and thought of you.
POOP COLLECTING
Persephone Biosciences
https://www.linkedin.com/posts/persephone-biosciences_a-mass-extinction-is-taking-place-in-the-activity-7016864965710024704-3mLi
Fascinating article, we love the poop collecting efforts by public health researcher Abdifatah Muhummed, collecting stool samples from children in a remote, pastoralist community in Ethiopia’s Somali Region. We believe the collection and study of fresh poop samples is essential to unlocking the secrets of the microbiome and the medicine of tomorrow.
A Mass Extinction Is Taking Place in the Human Gut
To preserve humankind’s diverse bacteria, scientists are harvesting, freezing, and storing poop from around the world.
https://www.wired.com/story/microbiota-vault/
Your work is important. We need to skip the politics and illuminate the darkness, because people are lost and suffering.
Gut tissues can retain SARS-CoV-2 particles after COVID-19 infection for more than one year after the resolution of COVID-19
Evinco Health
https://www.linkedin.com/posts/rachel-jessey_health-environmental-freshair-activity-7016743013699715072-TisK
Lung Health and the lung microbiome
Interesting concepts discussed here.
I have read through this interesting review and although the sole focus is not on SARS-CoV-2 infection there are some interesting concepts discussed in relation to the human lung microbiome and disease.
The authors conclude that there is a bi-directional relationship between microbial ecosystems and host susceptibility to infectious and other diseases.
1) Microbiomes may serve as the source of infection-causing pathogens
2) Invading pathogens have the ability to alter the host's microbial communities for extended periods of time.
Also discussed are the environmental insults that predispose not only hosts' tissues but also human microbiota to the disease development by changing microbial composition, host immunity, and epithelial integrity.
What was really interesting to me as a promoter of simple yet effective interventions is that there is mention of replenishing and promoting certain species from exposure to rich and healthy ambient air microbiomes (e.g. forest microbiome).
These are important concepts to consider when trying to understand the relationship between our environmental inputs, our microbiome interactions and health.
Human airway and lung microbiome at the crossroad of health and disease
https://www.spandidos-publications.com//10.3892/etm.2022.11718
In lieu of the "virus causing gut dysbiosis" information I was actually curious whether SARS-COV2 in the gut was a consequence of viral persistence or of prolonged dysbiosis. A few of the studies looking at viral persistence usually rely on PCR or presence of spike antigen which is interesting, but they don't provide us any information on the viability of the virus. One year would be really interesting because without routine follow-up you run into the issue of repeat infections or other variables muddying the assessment of that information.
I would lean more towards the idea that viral persistence may occur but the dynamics may likely be dependent upon the microenvironment, in that it's possible that those who already have altered gut microbiomes may be more susceptible to persistence due to the inability to properly produce barriers against viruses.
Thanks for the link! I mentioned something like that one of my other microbiome posts one reader left a comment about the Strep A rise, and I built off of the idea that masking would have inherently blocked bacteria but not viruses, and therefore the constant masking, especially outdoors, likely prevented enrichment from environmental microbes or the exchange of beneficial microbes between people, and this may be related to much of what's going on right now.
Like with all other comorbidities, dysbiosis should probably be considered its own comorbidity.
Dr Sabine Hazan MD (microbiome doctor) she looks at patients poop she uses whole genome sequencing.
SABINE HAZAN MD twitter
https://twitter.com/sabinehazanmd
Sabine Hazan MD website ⬇️
https://progenabiome.com/
Interesting! Her website immediately states this:
"If you are NOT VACCINATED for COVID-19 and you have NEVER TESTED POSITIVE for the virus, please consider donating your stool for research. "
I'm guessing she wants to scour feces to see why some people just don't get sick? That'd be an interesting place to look given the context of my current posts!
18 months some people still have viral reservoir far as I remember. If you look for Carlo Brogna on twitter, LinkedIn, Facebook etc he has just published a new study to add to his collection.
“the toxins produced by our bacteria (gut) can be when they replicate the SARS-CoV-2 virus; we show the data on vitro use of antibiotics to contrast not only the repl Viral ication in bacteria but also their toxicological production.”
If you look on twitter for “Vedicinals9 India Pvt Ltd” they do videos
“Comprehensive analysis of Covid and Long Covid driving mechanisms and Protocols for the management of these severe multisystemic condition”
Lots to learn from this doctor below on his page.
Dr. Gustavo Aguirre-Chang
https://twitter.com/aguirre1gustavo
Here’s the ROC curve for replication-competent SARS-CoV-2 virus using just RNA.
https://youtu.be/BxJxZfIhYnM
So I believe this is the study that is being referenced with the 18 month timeframe:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148128/
However, the title is mixing a few things together. In reading it apparently the patient reached a point during the first infection in which he began testing negative but his fecal samples were still testing positive. The length of time for positivity doesn't seem clear. They mention the nasopharyngeal testing appeared negative on day 10 so we can assume that the fecal tests maybe extended past that.
However, the 18 months is in reference to a reinfection with Omicron. The "Previous Case with Multiple Negative Nasopharyngeal Swab Tests and Positive Fecal Molecular Test" refers to the first infection, then the reinfection occurred 18 months out.
He apparently had this article which seems interesting:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143435/
I haven't read through it so I'm not sure what it includes but it'd be an interesting perspective to consider SARS-COV2 being a possible bacteriophage.
Thanks for the Twitter link as well. It appears he posts a lot of articles so it may be a good place to see what studies are out there.
There is more people at 18 months. You can test negative but actually be positive, Gustavo also comments on that and puts another one of his studies of a different test. It’s intracellular something like that. Also people shed it in poo one study it was shedding for a year. Oral fecal transmission has been known for a long time apparently there are many studies on it.