Magnesium inadequacy is likely due to spike effects on the ankyrin binding domain of TRP channels. Topical magnesium sources or chelated magnesium supplements are probably needed.
"These findings probably reflect consequences of high intracellular concentrations of Ca2+, and it has been proposed that Ca2+ overload in myocardial cells produces the ventricular dysfunction in catecholamine cardiotoxicity.20 "
Thanks for the remarks Jennifer, I do believe that several of the alpha and beta receptors that bind Epi/NE are involved with intracellular regulation of Ca. In many instances it does appear that Ca is a real driver of cardiovascular disease. I believe I mention it in my ER stress post linked above, however it's been a few months since I've looked into ER stress so I can't immediately recall what exactly was in that post.
Cadegiani looks like a very strong lead what with the connection to why young males (+athletes). Since metabolism isn't my thing I'm glad you're the one taking on a human-speak version of the paper. Top of my wish list is whether evidence of this pathology is presented in any nonfatal cases.
I had not heard of this before so thank you for bringing it to our attention. I think it really speaks to the fact that we are dealing with many things happening simultaneously within our bodies (and a bit differently between people) and trying to pigeon hole anything to the “end all” cause of vaccine injury is somewhat ludicrous.
Did you see Joomi’s post today as it is concerned with HeLa cell contamination (and how research on specific cancer cells weren’t exactly what they thought as they were actually HeLa cells) which again makes me think of the telomeres (Bret Weinstein). So in answer to your open thread: I think this past year has kinda been soul crushing for me as a scientist... as these sort of revelations should be.
Looking forward to learning more about catecholamines - keep up the excellent work!
Yes I just read it today! There are plenty of issues going on with science research and so it's hard to wrap your mind around the fact that many of the studies being cited may have egregious methodological issues. I think that's why it's important we examine studies within the given context rather than extrapolate too much.
The body is complex and there are a ton of things that could be going on, and to proclaim that anything is definitive is really difficult.
I'll give you the benefit of the doubt as to what you are alluding to with your question mejbcart, but let me emphasize a few points from this post.
First off, I never stated that my hypothesis involved catecholamines. I specifically stated that several hypotheses were circulating about mRNA vaccines and myocarditis, and I posted one that emphasized ER stress as I was doing research on Fluvoxamine which acts as a sigma-1 agonist. I never stated that my post was about catecholamines, and so I'm unsure why you made that assumption.
As to the catecholamine issue, it was brought to my attention in February when I made this post and someone mentioned the autopsy of the two adolescent males who dies days after receiving the mRNA vaccines, which too was released in February.
And as the autopsy stated, the evidence suggested catecholamine-induced stress on the heart, and that's where I first heard of the catecholamine link.
I also added the conclusion from the paper in my post above, which also clearly states that the deaths were associated with catecholamine-induced stress.
I started writing this post because I saw Dr. Cadegiani's hypothesis posted, which came out on August 11. However, this is the peer-reviewed version. In your article from March you cite this exact article, but likely it was a pre-print version. I decided to revisit the issue given the recent version released by Dr. Cadegiani and how it provided a template to examine the ideas further.
Again, I'm giving you the benefit of the doubt as to what you are trying to insinuate, but I also suggest you reread my post and see if you may have misconstrued my words.
Thanks for the explanation to make me believe that you never saw any of my posts and it is just your own guidance to write about whatever you feel important (that's why I'm mentioning telepathy_)
I'd be angry, if you saw my posts and started digging deeper, posted your stuff without citing the source of some info I posted. Just need to add, seeing your CT connection, the very same topic I was writing about (without using that term), made me 100% believe that's a targeted message here for me..
After all, these are just posts, describing parts of the truth, nature, etc. That's not on the same level which is going on in every scientific lab, stealing ideas, without citing the original, plagiat miseries....
Oh, with my previous remark, I'm just giving you the opportunity to know that' I'm writing about the very same topic too, so you can CITE and point to my posts in yours, in order not to duplicate stuff. Well, also I hope the money or AI's do not play any role here...
Magnesium inadequacy is likely due to spike effects on the ankyrin binding domain of TRP channels. Topical magnesium sources or chelated magnesium supplements are probably needed.
"These findings probably reflect consequences of high intracellular concentrations of Ca2+, and it has been proposed that Ca2+ overload in myocardial cells produces the ventricular dysfunction in catecholamine cardiotoxicity.20 "
Takotsubo Cardiomyopathy - A New Form of Acute, Reversible Heart Failure https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.108.767012
Epinephrine given in excess can cause Takotsubo cardiomyopathy, so elite athletes would be more at risk. https://www.researchgate.net/publication/26280099_Iatrogenic_epinephrine-induced_reverse_Takotsubo_cardiomyopathy_Direct_evidence_supporting_the_role_of_catecholamines_in_the_pathophysiology_of_the_broken_heart_syndrome
Thanks for the remarks Jennifer, I do believe that several of the alpha and beta receptors that bind Epi/NE are involved with intracellular regulation of Ca. In many instances it does appear that Ca is a real driver of cardiovascular disease. I believe I mention it in my ER stress post linked above, however it's been a few months since I've looked into ER stress so I can't immediately recall what exactly was in that post.
Thanks, I will try to have a look.
Thanks. Looking forward to the next installment!
Cadegiani looks like a very strong lead what with the connection to why young males (+athletes). Since metabolism isn't my thing I'm glad you're the one taking on a human-speak version of the paper. Top of my wish list is whether evidence of this pathology is presented in any nonfatal cases.
I had not heard of this before so thank you for bringing it to our attention. I think it really speaks to the fact that we are dealing with many things happening simultaneously within our bodies (and a bit differently between people) and trying to pigeon hole anything to the “end all” cause of vaccine injury is somewhat ludicrous.
Did you see Joomi’s post today as it is concerned with HeLa cell contamination (and how research on specific cancer cells weren’t exactly what they thought as they were actually HeLa cells) which again makes me think of the telomeres (Bret Weinstein). So in answer to your open thread: I think this past year has kinda been soul crushing for me as a scientist... as these sort of revelations should be.
Looking forward to learning more about catecholamines - keep up the excellent work!
Yes I just read it today! There are plenty of issues going on with science research and so it's hard to wrap your mind around the fact that many of the studies being cited may have egregious methodological issues. I think that's why it's important we examine studies within the given context rather than extrapolate too much.
The body is complex and there are a ton of things that could be going on, and to proclaim that anything is definitive is really difficult.
Your 24Feb post didn't mentioned catecholamines. I wrote one of my first substack article's linking CATECHOLAMINES and the SARS-CoV-2 spike issue:
https://mejbcart.substack.com/p/dipeptides-catecholamines-and-sars
My newest post from Jul 24th on catecholamines:
https://mejbcart.substack.com/p/catecholamines-5g-and-the-deaths
Must be some kind of strange coincidences that people start writing about the same thing, isn't it?
I'll give you the benefit of the doubt as to what you are alluding to with your question mejbcart, but let me emphasize a few points from this post.
First off, I never stated that my hypothesis involved catecholamines. I specifically stated that several hypotheses were circulating about mRNA vaccines and myocarditis, and I posted one that emphasized ER stress as I was doing research on Fluvoxamine which acts as a sigma-1 agonist. I never stated that my post was about catecholamines, and so I'm unsure why you made that assumption.
As to the catecholamine issue, it was brought to my attention in February when I made this post and someone mentioned the autopsy of the two adolescent males who dies days after receiving the mRNA vaccines, which too was released in February.
https://moderndiscontent.substack.com/p/when-things-are-finally-over-what/comments?s=w
And as the autopsy stated, the evidence suggested catecholamine-induced stress on the heart, and that's where I first heard of the catecholamine link.
I also added the conclusion from the paper in my post above, which also clearly states that the deaths were associated with catecholamine-induced stress.
I started writing this post because I saw Dr. Cadegiani's hypothesis posted, which came out on August 11. However, this is the peer-reviewed version. In your article from March you cite this exact article, but likely it was a pre-print version. I decided to revisit the issue given the recent version released by Dr. Cadegiani and how it provided a template to examine the ideas further.
Again, I'm giving you the benefit of the doubt as to what you are trying to insinuate, but I also suggest you reread my post and see if you may have misconstrued my words.
Thanks for the explanation to make me believe that you never saw any of my posts and it is just your own guidance to write about whatever you feel important (that's why I'm mentioning telepathy_)
I'd be angry, if you saw my posts and started digging deeper, posted your stuff without citing the source of some info I posted. Just need to add, seeing your CT connection, the very same topic I was writing about (without using that term), made me 100% believe that's a targeted message here for me..
After all, these are just posts, describing parts of the truth, nature, etc. That's not on the same level which is going on in every scientific lab, stealing ideas, without citing the original, plagiat miseries....
Oh, with my previous remark, I'm just giving you the opportunity to know that' I'm writing about the very same topic too, so you can CITE and point to my posts in yours, in order not to duplicate stuff. Well, also I hope the money or AI's do not play any role here...