I completely forgot to add: In the wake of all of this talk about boosters there should be serious concern about OAS occurring with the Adenovirus based vaccines. The vectors used are Chimp/recombinant derived adenoviruses because there is concern that using human adenovirus vectors in populations where adenoviruses are common may prevent proper vaccination due to the immune system targeting/eliminating the vector before it can induce spike protein formation.
It would make sense then that using a 2nd dose of one of the adenovirus vectors would prove very ineffective due to OAS and prior immune memory.
If you look at vaccine uptake by age group vs N prevalence by age you will also see a correlation.
I completely forgot to add: In the wake of all of this talk about boosters there should be serious concern about OAS occurring with the Adenovirus based vaccines. The vectors used are Chimp/recombinant derived adenoviruses because there is concern that using human adenovirus vectors in populations where adenoviruses are common may prevent proper vaccination due to the immune system targeting/eliminating the vector before it can induce spike protein formation.
It would make sense then that using a 2nd dose of one of the adenovirus vectors would prove very ineffective due to OAS and prior immune memory.