While I do see absolute value in the use of Evusheld as a prophylactic for immuno-compromised individuals, I still have several questions in general. I have been a bit stuck on secretory IgA for a while. I see people claiming that is the reason the vaccines are useless is because the vaccines promote the production of IgG or IgM antibodies and not IgA. Considering that the virus enters via the respiratory tract, then having SIgA would be the best candidate to neutralize the virus prior to it binding ACEII and gaining entry into our cells. Again, I have seen studies which claim that Pfizer's vaccine did indeed illicit the creation of SIgA (as did natural infection). Yet, I wouldn't claim that the vaccine induced antibodies are doing a great job at protecting from infection (maybe this is just immune escape caused by variants or maybe the vaccine created spike is actually too different from natural spike due to the optimization done by pharmaceutical companies). Also, with the neutralization assays used they are literally combining things in a test tube and saying "look, it bound" - it doesn't necessarily mean that these antibodies/antigens will come into contact with each other in the body).
As Evusheld is an intramuscular shot of mABs which would quickly enter the bloodstream and circulate for a pretty long time (and be well tolerated by the body as they do appear to be a normal thing seen in the human body). Note, I just said an IM shot will quickly enter the bloodstream - yes, I just looked that up (https://www.ncbi.nlm.nih.gov/books/NBK556121/) - so total lie, that the vaccine just stays in those cells around the injection site. But I digress, I am wondering if (and I presume Evusheld is IgG isotype) the IgG antibodies wouldn't be considered neutralizing, but rather more as a defense against infected cells as IgG can activate the complement system destroying infected cells.
Sorry for this stream of consciousness comment - there are just so many questions and so few actually useful answers and I just have this desire for all of this to make sense (and it just doesn't). One last comment - I dug up the federal contract award for this drug... just to see how much it cost: https://govtribe.com/award/federal-contract-award/other-transaction-agreement-w911qy2190001
Jul 28, 2022·edited Jul 28, 2022Liked by Modern Discontent
Personally, I'd rather take my herbal combo of immune support, Astragalus, Eleuthero, Rhodiola and Antivirals Chinese skullcap, kudzu, Isatis. There's others but these are my core group
While I do see absolute value in the use of Evusheld as a prophylactic for immuno-compromised individuals, I still have several questions in general. I have been a bit stuck on secretory IgA for a while. I see people claiming that is the reason the vaccines are useless is because the vaccines promote the production of IgG or IgM antibodies and not IgA. Considering that the virus enters via the respiratory tract, then having SIgA would be the best candidate to neutralize the virus prior to it binding ACEII and gaining entry into our cells. Again, I have seen studies which claim that Pfizer's vaccine did indeed illicit the creation of SIgA (as did natural infection). Yet, I wouldn't claim that the vaccine induced antibodies are doing a great job at protecting from infection (maybe this is just immune escape caused by variants or maybe the vaccine created spike is actually too different from natural spike due to the optimization done by pharmaceutical companies). Also, with the neutralization assays used they are literally combining things in a test tube and saying "look, it bound" - it doesn't necessarily mean that these antibodies/antigens will come into contact with each other in the body).
As Evusheld is an intramuscular shot of mABs which would quickly enter the bloodstream and circulate for a pretty long time (and be well tolerated by the body as they do appear to be a normal thing seen in the human body). Note, I just said an IM shot will quickly enter the bloodstream - yes, I just looked that up (https://www.ncbi.nlm.nih.gov/books/NBK556121/) - so total lie, that the vaccine just stays in those cells around the injection site. But I digress, I am wondering if (and I presume Evusheld is IgG isotype) the IgG antibodies wouldn't be considered neutralizing, but rather more as a defense against infected cells as IgG can activate the complement system destroying infected cells.
Sorry for this stream of consciousness comment - there are just so many questions and so few actually useful answers and I just have this desire for all of this to make sense (and it just doesn't). One last comment - I dug up the federal contract award for this drug... just to see how much it cost: https://govtribe.com/award/federal-contract-award/other-transaction-agreement-w911qy2190001
Personally, I'd rather take my herbal combo of immune support, Astragalus, Eleuthero, Rhodiola and Antivirals Chinese skullcap, kudzu, Isatis. There's others but these are my core group