Upon its introduction, Prozac was lauded within the psychiatric community as a panacea drug, and we continue to live with the abominable fallout. Venoms, as found in the Ozempic class drugs, present unique problems within the body, accumulation over time being one, hence the heinous 'side effects.' How organ destruction can be viewed as neglible by medical practitioners escapes all reasoned thought.
First off, I urge you to not give ideas of mandated GLP-1 vaccines. It is bad enough that there are nut cases forcing similar ones already.
Secondly, there are people among us that are called early adopters. These people will drink urine if it is they are told is the next advancement. You cannot stop them. They have their complexes and they address their shortcomings by opining on everything :).
However, we can thank them for letting us see things we would never know in terms of biochemistry. As George tells Jerry, 'who are we to play God?' :)
Obesity is in part caused by excessive inflammation (indiscriminate cell-destroying immune responses) which are worsened by low circulating 25-hydroxyvitamin D levels and are to a large extent caused, (with significant individual genetic variation) by most humans, at least in developed countries, no longer being infested with helminths - intestinal worms.
The adaptive immune responses which work best against viruses, bacteria, cancer cells, yeast and fungi cells - antibodies and macrophages - are ineffective against multicellular parasites such as helminths, which have thick protective layers of cells. Indiscriminate cell-destroying immune responses have evolved to tackle such parasites. For instance eosinophils - the suicide bombers of the immune system - arrive on the scene, disintegrate and release the contents of the vacuoles which contain enzymes which destroy DNA, RNA and proteins. Other type of immune cells, such as Th1 regulatory lymphocytes, control the activities of these cell-destroying immune cells, which kill host and parasite cells indiscriminately.
Helminths long ago (in mammalian or perhaps earlier vertebrate evolution) evolved to exude one or more compounds which down-modulate these inflammatory immune responses which target them. The response of the hosts - our ancestors going back well before the evolution of humans and probably primates in general - was to evolve stronger indiscriminate cell-destroying immune responses, in the expectation that these would be down-modulated by ubiquitous helminth infections. Now we are all de-wormed, we have excessively strong, self-destructive, inflammatory, indiscriminate cell destroying immune responses.
To make matters much worse, most people have only a fraction of the 50 ng/mL 125 nmol/L of the circulating 25-hydroxyvitamin D their immune systems need to function properly. This is needed for individual immune cells (of many types) intracrine and paracrine signaling systems, which communicate within each cell, and to nearby cells, respectively, information the cells need in order to respond to their changing circumstances.
This includes especially the ability of Th1 regulatory lymphocytes to transition from their pro-inflammatory startup program to their anti-inflammatory shutdown program when they detect the conditions to do so (a high level of a complement protein). See Chauss et al. 2021 https://www.nature.com/articles/s41590-021-01080-3https://vitamindstopscovid.info/00-evi/#chauss regarding Th1 regulatory lymphocytes from the lungs of hospitalised COVID-19 patients failing to transition from their pro-inflammatory start-up program to their anti-inflammatory shutdown program, despite detecting the condition to do so. This failure of the Th1 cell's 25(OH)D based intracrine signaling system was due primarily or wholly to inadequate supplies of 25(OH)D.
Furthermore, obesity reduces circulating levels of 25-hydroxyvitamin D for any given intake (or UV-B skin production) of vitamin D3, as a ratio of body weight. There are at least two reasons for this. Firstly, lower rates of hydroxylation, primarily in the liver and secondly greater sequestration of 25-hydroxyvitamin D (and probably vitamin D3 cholecalciferol before it can be hydroxylated) in the excess adipose tissue: https://vitamindstopscovid.info/00-evi/#obesity-deficit.
Chronic diseases, as well as infectious diseases, cancer, neurodegeneration (dementia, Parkinson's, Alzheimer's) diseases and antibiotic-resistant bacteria would be much less of a problem if everyone had at least the 50 ng/mL (125 nmol/L) circulating 25-hydroxyvitamin D, which the immune system needs to function properly. Please see the research cited and discussed at: https://vitamindstopscovid.info/00-evi/. Without proper vitamin D3 supplementation most people have only half the 25-hydroxyvitamin D they need to be healthy, at least in winter.
For newborns, and for their proper development in utero, this means the mother, from early days of gestation, needs at least this 50 ng/mL (1 part in 20,000,000 by mass) level of 25-hydroxyvitamin D. This is 2.5 times what most doctors think is adequate for health - 20 ng/mL 50 nmol/L which is sufficient for the kidneys to perform the one hormonal function of the vitamin D compounds: regulating calcium-phosphate-bone metabolism. The problems begin before birth: https://vitamindstopscovid.info/00-evi/#3.2, with preeclampsia, pre-term birth, sepsis and the later development of autism, ADHD, intellectual disability and schizophrenia.
Neither vitamin D3 cholecalciferol nor 25-hydroxyvitamin D (as tested in "vitamin D" blood tests, made in the liver, over days, from ingested or UV-B-->skin produced vitamin D3) are hormones. These are not signaling molecules. The immune system does not use hormonal (endocrine) signaling.
Because there is very little vitamin D3 in food, fortified or not, and because UV-B skin exposure is hard to obtain all year round - and damages DNA and so raises the risk of skin cancer - most people require vitamin D3 supplementation in quantities which, while small (0.125 mg 5000 IU a day on average - for 70 kg 154 lb body weight without obesity), are about 8 times greater than what governments and many doctors recommend.
"5000 IUs a day" sounds like a lot, but it is 1/8000th of a gram = 1 gram every 22 years. Pharma grade vitamin D3 costs about USD$2.50 a gram ex-factory. A credit card weighs 5 grams.
My 78-yr-old mother told me recently that "all her friends" were on Ozempic for weight loss. I was horrified! Was this even trialed in elderly people? I know her friends--none of them are obese. They have the typical rounded grandma figure of 70- and 80-yr-old women. My own mother is slimmer than most, and I begged her not to start it. It was only this fall that I got my parents to avoid covid boosters--with some info I've learned here!
Upon its introduction, Prozac was lauded within the psychiatric community as a panacea drug, and we continue to live with the abominable fallout. Venoms, as found in the Ozempic class drugs, present unique problems within the body, accumulation over time being one, hence the heinous 'side effects.' How organ destruction can be viewed as neglible by medical practitioners escapes all reasoned thought.
First off, I urge you to not give ideas of mandated GLP-1 vaccines. It is bad enough that there are nut cases forcing similar ones already.
Secondly, there are people among us that are called early adopters. These people will drink urine if it is they are told is the next advancement. You cannot stop them. They have their complexes and they address their shortcomings by opining on everything :).
However, we can thank them for letting us see things we would never know in terms of biochemistry. As George tells Jerry, 'who are we to play God?' :)
Obesity is in part caused by excessive inflammation (indiscriminate cell-destroying immune responses) which are worsened by low circulating 25-hydroxyvitamin D levels and are to a large extent caused, (with significant individual genetic variation) by most humans, at least in developed countries, no longer being infested with helminths - intestinal worms.
The adaptive immune responses which work best against viruses, bacteria, cancer cells, yeast and fungi cells - antibodies and macrophages - are ineffective against multicellular parasites such as helminths, which have thick protective layers of cells. Indiscriminate cell-destroying immune responses have evolved to tackle such parasites. For instance eosinophils - the suicide bombers of the immune system - arrive on the scene, disintegrate and release the contents of the vacuoles which contain enzymes which destroy DNA, RNA and proteins. Other type of immune cells, such as Th1 regulatory lymphocytes, control the activities of these cell-destroying immune cells, which kill host and parasite cells indiscriminately.
Helminths long ago (in mammalian or perhaps earlier vertebrate evolution) evolved to exude one or more compounds which down-modulate these inflammatory immune responses which target them. The response of the hosts - our ancestors going back well before the evolution of humans and probably primates in general - was to evolve stronger indiscriminate cell-destroying immune responses, in the expectation that these would be down-modulated by ubiquitous helminth infections. Now we are all de-wormed, we have excessively strong, self-destructive, inflammatory, indiscriminate cell destroying immune responses.
To make matters much worse, most people have only a fraction of the 50 ng/mL 125 nmol/L of the circulating 25-hydroxyvitamin D their immune systems need to function properly. This is needed for individual immune cells (of many types) intracrine and paracrine signaling systems, which communicate within each cell, and to nearby cells, respectively, information the cells need in order to respond to their changing circumstances.
This includes especially the ability of Th1 regulatory lymphocytes to transition from their pro-inflammatory startup program to their anti-inflammatory shutdown program when they detect the conditions to do so (a high level of a complement protein). See Chauss et al. 2021 https://www.nature.com/articles/s41590-021-01080-3 https://vitamindstopscovid.info/00-evi/#chauss regarding Th1 regulatory lymphocytes from the lungs of hospitalised COVID-19 patients failing to transition from their pro-inflammatory start-up program to their anti-inflammatory shutdown program, despite detecting the condition to do so. This failure of the Th1 cell's 25(OH)D based intracrine signaling system was due primarily or wholly to inadequate supplies of 25(OH)D.
Furthermore, obesity reduces circulating levels of 25-hydroxyvitamin D for any given intake (or UV-B skin production) of vitamin D3, as a ratio of body weight. There are at least two reasons for this. Firstly, lower rates of hydroxylation, primarily in the liver and secondly greater sequestration of 25-hydroxyvitamin D (and probably vitamin D3 cholecalciferol before it can be hydroxylated) in the excess adipose tissue: https://vitamindstopscovid.info/00-evi/#obesity-deficit.
Chronic diseases, as well as infectious diseases, cancer, neurodegeneration (dementia, Parkinson's, Alzheimer's) diseases and antibiotic-resistant bacteria would be much less of a problem if everyone had at least the 50 ng/mL (125 nmol/L) circulating 25-hydroxyvitamin D, which the immune system needs to function properly. Please see the research cited and discussed at: https://vitamindstopscovid.info/00-evi/. Without proper vitamin D3 supplementation most people have only half the 25-hydroxyvitamin D they need to be healthy, at least in winter.
For newborns, and for their proper development in utero, this means the mother, from early days of gestation, needs at least this 50 ng/mL (1 part in 20,000,000 by mass) level of 25-hydroxyvitamin D. This is 2.5 times what most doctors think is adequate for health - 20 ng/mL 50 nmol/L which is sufficient for the kidneys to perform the one hormonal function of the vitamin D compounds: regulating calcium-phosphate-bone metabolism. The problems begin before birth: https://vitamindstopscovid.info/00-evi/#3.2, with preeclampsia, pre-term birth, sepsis and the later development of autism, ADHD, intellectual disability and schizophrenia.
Neither vitamin D3 cholecalciferol nor 25-hydroxyvitamin D (as tested in "vitamin D" blood tests, made in the liver, over days, from ingested or UV-B-->skin produced vitamin D3) are hormones. These are not signaling molecules. The immune system does not use hormonal (endocrine) signaling.
New Jersey based Professor of Medicine Sunil Wimalawansa has recommendations for how much vitamin D3 to supplement, on average per day, to attain at least 50 ng/mL circulating 25-hydroxyvitamin D, without the need for blood tests or medical monitoring. The amount depends on body weight and obesity status: https://vitamindstopscovid.info/00-evi/#00-how-much. These are based on his article: "Rapidly Increasing Serum 25(OH)D Boosts the Immune System, against Infections - Sepsis and COVID-19" Nutrients 2022-07-21 http://www.mdpi.com/2072-6643/14/14/2997 as simplified somewhat in his FLCCC webinar: https://odysee.com/@FrontlineCovid19CriticalCareAlliance:c/Weeekly_Webinar_Aug16_2023:d?t=3386.
Because there is very little vitamin D3 in food, fortified or not, and because UV-B skin exposure is hard to obtain all year round - and damages DNA and so raises the risk of skin cancer - most people require vitamin D3 supplementation in quantities which, while small (0.125 mg 5000 IU a day on average - for 70 kg 154 lb body weight without obesity), are about 8 times greater than what governments and many doctors recommend.
"5000 IUs a day" sounds like a lot, but it is 1/8000th of a gram = 1 gram every 22 years. Pharma grade vitamin D3 costs about USD$2.50 a gram ex-factory. A credit card weighs 5 grams.
My 78-yr-old mother told me recently that "all her friends" were on Ozempic for weight loss. I was horrified! Was this even trialed in elderly people? I know her friends--none of them are obese. They have the typical rounded grandma figure of 70- and 80-yr-old women. My own mother is slimmer than most, and I begged her not to start it. It was only this fall that I got my parents to avoid covid boosters--with some info I've learned here!