I would have to disagree with you on this being a fad. Unfortunately, there seem to be far too many incentive structures at play that are upholding the utility of these medications. They're alleged to be helpful for diabetes, weight-loss, Alzheimer's, cardiovascular disease, etc etc.
What I think doesn't get talked about to often, and something that seems rather insidious, is that these medications are now being considered for both chronic and preventative measures. Take that these medications are being studied on prediabetics, a whole slew of people who may never go on to develop diabetes. But by targeting this group you can widen your user base.
Then take the fact that people are investigating the effects of these drugs on addiction. This opens up new avenues in research as it would help to better understand the underlying players in addiction, and in some sense it would be a useful tool to help people fight addiction. But what if the use extends further than that- if these drugs can be shown to treat addiction then what would stop people from forcing mandates on addicts to take these medications? Imagine if people found to be taking illicit drugs or alcohol are forced to take these medications as part of their plea or sentencing. Or what if people who go to AA meetings must require that they show proof of being on these medications as a sign that they are treating their addiction?
Or what about people who may show addictive signs- should they be given these medications as a preventative? I believe there were remarks where they wanted to give these medications to everyone as a preventative measure.
It's unfortunate that many people, especially among those within the COVID vaccine critical community, aren't considering greater ramifications with these drugs. I think there's a lot to be concerned about and I don't think it will disappear anytime soon.
Our differing views might be from living in different communities. Mine rejected the COVID narrative pretty quickly, and they’re turning away from these GLP1 agonists similarly. It’s a bummer to be nauseated all the time or to have longstanding gastroparesis or obstruction. These drugs are very expensive. I don’t know how most people afford them.
By the way, it’s been routine to investigate just about any new molecule or natural product for effects on Alzheimer’s for many years, at least in animal models. No magic bullet is forthcoming.
For millennia it was not possible to know exactly how any drugs worked. Now we are able to discern partial mechanisms for many of the drugs. One can't assume that if one mechanism of action is found for a drug that it's the only mechanism, or that it doesn't influence many other processes.
Mechanisms of action for drugs is an interesting topic. It partially runs on the idea that you don't know what something does until you yuck up its processes.
Funnily enough, this is how many agents become prospective therapeutics- you give a compound that targets some sort of enzyme or cellular process, find out it blocks it, but then find out that blocking that pathway may help treat some disease. Some of the research going on into GLP-1 and its role in the body is driven by these receptor agonists, it's just a shame that the research also enforces a dependency on these medications rather than understanding the natural mechanism inside all of us.
I think many medications used right now have unknown mechanisms of action. I believe even some over the counter pain medications still have unknown mechanisms of action.
Like many medical fads, this one will pass. It's messing too many people up, sometimes permanently.
I would have to disagree with you on this being a fad. Unfortunately, there seem to be far too many incentive structures at play that are upholding the utility of these medications. They're alleged to be helpful for diabetes, weight-loss, Alzheimer's, cardiovascular disease, etc etc.
What I think doesn't get talked about to often, and something that seems rather insidious, is that these medications are now being considered for both chronic and preventative measures. Take that these medications are being studied on prediabetics, a whole slew of people who may never go on to develop diabetes. But by targeting this group you can widen your user base.
Then take the fact that people are investigating the effects of these drugs on addiction. This opens up new avenues in research as it would help to better understand the underlying players in addiction, and in some sense it would be a useful tool to help people fight addiction. But what if the use extends further than that- if these drugs can be shown to treat addiction then what would stop people from forcing mandates on addicts to take these medications? Imagine if people found to be taking illicit drugs or alcohol are forced to take these medications as part of their plea or sentencing. Or what if people who go to AA meetings must require that they show proof of being on these medications as a sign that they are treating their addiction?
Or what about people who may show addictive signs- should they be given these medications as a preventative? I believe there were remarks where they wanted to give these medications to everyone as a preventative measure.
It's unfortunate that many people, especially among those within the COVID vaccine critical community, aren't considering greater ramifications with these drugs. I think there's a lot to be concerned about and I don't think it will disappear anytime soon.
Our differing views might be from living in different communities. Mine rejected the COVID narrative pretty quickly, and they’re turning away from these GLP1 agonists similarly. It’s a bummer to be nauseated all the time or to have longstanding gastroparesis or obstruction. These drugs are very expensive. I don’t know how most people afford them.
By the way, it’s been routine to investigate just about any new molecule or natural product for effects on Alzheimer’s for many years, at least in animal models. No magic bullet is forthcoming.
I can't believe drugs can be given to people without us knowing EXACTLY how they work 🤦🏻♀️
For millennia it was not possible to know exactly how any drugs worked. Now we are able to discern partial mechanisms for many of the drugs. One can't assume that if one mechanism of action is found for a drug that it's the only mechanism, or that it doesn't influence many other processes.
Exactly! I can think of a few new products that didn't work how they were assumed to 😳
Mechanisms of action for drugs is an interesting topic. It partially runs on the idea that you don't know what something does until you yuck up its processes.
Funnily enough, this is how many agents become prospective therapeutics- you give a compound that targets some sort of enzyme or cellular process, find out it blocks it, but then find out that blocking that pathway may help treat some disease. Some of the research going on into GLP-1 and its role in the body is driven by these receptor agonists, it's just a shame that the research also enforces a dependency on these medications rather than understanding the natural mechanism inside all of us.
I think many medications used right now have unknown mechanisms of action. I believe even some over the counter pain medications still have unknown mechanisms of action.