Oct 17, 2022·edited Oct 17, 2022Liked by Modern Discontent
Someone please correct me if I'm wrong, but the mRNA sequencing is an approximation of synthesizing that which approximates the target spike protein. Based on the demanding storage requirements, instability of mRNA, each cell's ability to process the mRNA, the possibility of mutation and reading wrong, all could create misfolds.
Secondly, this approximated possibly misfolded, unnatural protein may then change shape as it moves through the body due to temperature or pH changes and the havoc it could cause is quite unknown because it hasn't been studied in detail or through adverse events because they don't seem to be researched much, are ignored in clinical trials or in the real world, people are told "we don't know" or "you can go home".
Moreover, with the use of LNPs the mRNA can also cross the blood brain barrier creating the approximated, unnatural and possibly misfolded proteins among brain cells as well. With the frosting on the cake, being we don't know how long before this all stops due to the possibility of saRNA and reverse transcriptase.
Lastly, the cherry on top, mice are mice and humans are humans.
(I won't even touch on the possibility of graphene oxide for now.)
If I'm wrong about this please let me know. These things worry me much more than the infectiousness ness of the strain involved. My apologies, if my comments are out of place.
Oct 17, 2022·edited Oct 17, 2022Liked by Modern Discontent
In the real world is the WT more infectious than Omicron? No, correct? Isn't that true both for vaccinated and unvaccinated? What is the explanation for why an older version of the virus is more infectious than Omicron? That doesn't fit with observed reality.
Let's all put on our "Geert Vanden Bossche hats" and then ask whether there would be differences in "intrinsic" infectiousness vs. vaccine antibody enhanced infectiousness. In other words, what about comparing vaccinated vs. unvaccinated mice? After all that's representative of the current human population.
It is an interesting study; of course it should have been assumed as unlikely from the start that the heavy mutations outside of spike had zero influence on virulence, and this non-zero influence was likely an attenuating one given that it's a milder variant. Pity it's been a year and no one's done a gene-by-gene teardown. But a one-gene teardown is better than nothing.
The response has been funny. As I've said before Omicron is an obvious lab creation and so if someone out there wants to release something less friendly, they're going to do it anyway.
Besides that, there are extreme differences in the non-spike region of BA.2 and as my origin analysis hints there could have been some pressure to resolve a secondary structure conflict* (Orf 1 ns and s selection pressure as noted in my timeline https://unglossed.substack.com/p/omicron-origins-part-1). If this was hammered out in BA.2 then it could already be matching "Omi-S" in terms of virulence in these same assays. Who knows. All we can do is speculate for now.
*For example, a single-point defect in the 5'UTR secondary structure is the main driver of attenuation in two of the polio strains in OPV.
Look. I don't want them doing any of this viral genetic testing/altering/research. Have we not discovered over the last 2 years that these "experiments" have the potential to destroy society? This kind of research is like living next door to a polluting factory. I get none of the benefits from it, nor have I consented to have my environment destroyed. Where are the benefits of this viral research?
Me thinks you are missing the forest for the trees. GOF on Sars-Cov-2 should not be funded by the government. Period.
Also, we know in the real world Omicron is far more infectious and transmits more extensively than WT, otherwise Chinas population would have been decimated in the first wave and in the US it would have affected more states.
We also know the reason Omicron has a lower CFR is it does not replicate well in the lungs. Super Omicron replicates well in the lungs. Thats a problem.
Now other labs having this capability could seek to duplicate the experiment for nefarious purposes, or not, and may do so in labs less secure (BSL-2)
Thanks this is useful context but it is time the scientific world took a stand against all gain of function research. This paper must be retracted and must not be allowed to be published. We have done this before with unethical studies and only once we start imposing these ethical standards will trust ever start to come back.
Another good point is that cells in test tube are simply cells n a test tube - once exposed to the virus there is literally nothing to prevent them from being infected. Humans have an innate immune system which can prevent you from being infected in the first place. We are exposed to potential pathogens all the time, yet we are not always sick!
I had WT and lived. Basically everyone I know who has had Covid has been fine (except for my dad who was in very poor health). I have been exposed several times to people with Omicron and have not been reinfected (I even spent 2 days in very close proximity to a trainee who ended up testing positive). I never did despite being subjected to several PCR tests.
12-20 weeks isn't really the age used for an "aged" mouse model but it still seems to make a difference here. Or nothing explains the difference. Another day, another replication crisis.
Wonderful post, thank you for calmly pointing all these things out.
"And that brings us to the real question here: what the heck was the point of this study?" Perhaps simply to continue the fear narrative, "there will be a killer virus in the future that we will need more vaccine injections for".
I am just a layperson, but the graphs discussed all show omicron to be inferior to Wuhan by every metric, yet we know that omicron is a lot more contagious in humans today than the Wuhan variant a couple of years ago. Is it possible that this chimera would be as contagious as omicron and almost as deadly as Wuhan? Sorry if this is a dumb question.
Also, what sort of laboratory did the scientists use for this work? Wuhan's laboratory was not secure enough to keep their virus contained, and I wonder about Boston University's laboratory.
I consider this "S" variant a false flag.
The real concern is a genuine more lethal variant on the way, totally engineered of course.
Almost like this "S" variant gives them and others some deniability, "See we told you, Geert was right!"
Someone please correct me if I'm wrong, but the mRNA sequencing is an approximation of synthesizing that which approximates the target spike protein. Based on the demanding storage requirements, instability of mRNA, each cell's ability to process the mRNA, the possibility of mutation and reading wrong, all could create misfolds.
Secondly, this approximated possibly misfolded, unnatural protein may then change shape as it moves through the body due to temperature or pH changes and the havoc it could cause is quite unknown because it hasn't been studied in detail or through adverse events because they don't seem to be researched much, are ignored in clinical trials or in the real world, people are told "we don't know" or "you can go home".
Moreover, with the use of LNPs the mRNA can also cross the blood brain barrier creating the approximated, unnatural and possibly misfolded proteins among brain cells as well. With the frosting on the cake, being we don't know how long before this all stops due to the possibility of saRNA and reverse transcriptase.
Lastly, the cherry on top, mice are mice and humans are humans.
(I won't even touch on the possibility of graphene oxide for now.)
If I'm wrong about this please let me know. These things worry me much more than the infectiousness ness of the strain involved. My apologies, if my comments are out of place.
Related articles:
https://www.forbes.com/sites/robtoews/2021/10/03/alphafold-is-the-most-important-achievement-in-ai-ever/
https://www.nature.com/articles/d41586-021-02483-w
In the real world is the WT more infectious than Omicron? No, correct? Isn't that true both for vaccinated and unvaccinated? What is the explanation for why an older version of the virus is more infectious than Omicron? That doesn't fit with observed reality.
Let's all put on our "Geert Vanden Bossche hats" and then ask whether there would be differences in "intrinsic" infectiousness vs. vaccine antibody enhanced infectiousness. In other words, what about comparing vaccinated vs. unvaccinated mice? After all that's representative of the current human population.
That's the real question that no researcher dare examine. And frankly I think the arguments against this research are very strong. Karl Denninger puts it bluntly here: https://market-ticker.org/akcs-www?blog=Market-Ticker-Nad
It is an interesting study; of course it should have been assumed as unlikely from the start that the heavy mutations outside of spike had zero influence on virulence, and this non-zero influence was likely an attenuating one given that it's a milder variant. Pity it's been a year and no one's done a gene-by-gene teardown. But a one-gene teardown is better than nothing.
The response has been funny. As I've said before Omicron is an obvious lab creation and so if someone out there wants to release something less friendly, they're going to do it anyway.
Besides that, there are extreme differences in the non-spike region of BA.2 and as my origin analysis hints there could have been some pressure to resolve a secondary structure conflict* (Orf 1 ns and s selection pressure as noted in my timeline https://unglossed.substack.com/p/omicron-origins-part-1). If this was hammered out in BA.2 then it could already be matching "Omi-S" in terms of virulence in these same assays. Who knows. All we can do is speculate for now.
*For example, a single-point defect in the 5'UTR secondary structure is the main driver of attenuation in two of the polio strains in OPV.
“what the heck was the point of this study?”
That question was just rolling around my brain
Look. I don't want them doing any of this viral genetic testing/altering/research. Have we not discovered over the last 2 years that these "experiments" have the potential to destroy society? This kind of research is like living next door to a polluting factory. I get none of the benefits from it, nor have I consented to have my environment destroyed. Where are the benefits of this viral research?
Me thinks you are missing the forest for the trees. GOF on Sars-Cov-2 should not be funded by the government. Period.
Also, we know in the real world Omicron is far more infectious and transmits more extensively than WT, otherwise Chinas population would have been decimated in the first wave and in the US it would have affected more states.
We also know the reason Omicron has a lower CFR is it does not replicate well in the lungs. Super Omicron replicates well in the lungs. Thats a problem.
Now other labs having this capability could seek to duplicate the experiment for nefarious purposes, or not, and may do so in labs less secure (BSL-2)
Thanks this is useful context but it is time the scientific world took a stand against all gain of function research. This paper must be retracted and must not be allowed to be published. We have done this before with unethical studies and only once we start imposing these ethical standards will trust ever start to come back.
Another good point is that cells in test tube are simply cells n a test tube - once exposed to the virus there is literally nothing to prevent them from being infected. Humans have an innate immune system which can prevent you from being infected in the first place. We are exposed to potential pathogens all the time, yet we are not always sick!
I had WT and lived. Basically everyone I know who has had Covid has been fine (except for my dad who was in very poor health). I have been exposed several times to people with Omicron and have not been reinfected (I even spent 2 days in very close proximity to a trainee who ended up testing positive). I never did despite being subjected to several PCR tests.
A bit of a funny follow-up - another spike recomb study but with no weight loss for any of the Omi spike mutants. Mice were 8-10 week female only instead of 12-20 weeks m+f https://www.biorxiv.org/content/10.1101/2022.11.08.515725v1
12-20 weeks isn't really the age used for an "aged" mouse model but it still seems to make a difference here. Or nothing explains the difference. Another day, another replication crisis.
Wonderful post, thank you for calmly pointing all these things out.
"And that brings us to the real question here: what the heck was the point of this study?" Perhaps simply to continue the fear narrative, "there will be a killer virus in the future that we will need more vaccine injections for".
I am just a layperson, but the graphs discussed all show omicron to be inferior to Wuhan by every metric, yet we know that omicron is a lot more contagious in humans today than the Wuhan variant a couple of years ago. Is it possible that this chimera would be as contagious as omicron and almost as deadly as Wuhan? Sorry if this is a dumb question.
Also, what sort of laboratory did the scientists use for this work? Wuhan's laboratory was not secure enough to keep their virus contained, and I wonder about Boston University's laboratory.