Very interesting article- this is the sort of data we ought to have by now. It is a good start and you have raised several great follow-ups to this study.
Overall the data does show a ton of variability between subjects which totally illustrates the complexity of the immune system & the differences between our immune statuses (health of our immune systems at the time of infection). It seems like most things are presented by the powers that be as being black & white, but immunology is nothing but gray!
Yes, by all accounts this is exactly the type of information I would hope for. It's almost as close as we can get to creating individual profiles which can tell us a story.
I'm going to try to post concluding remarks later today, but you've highlighted all of the things I wanted to state. The variability shows us how different we all are. We won't get clear black and white answers because each of us aren't black and white individuals (health-wise, at least!) so to assume that it would be so easy to pinpoint every little nuance would be nearly impossible.
We should always be aware of the fact that we are all different and that means we deal with things differently.
So interesting! My sister-in-law is a primary care dr who has never contracted covid despite her family getting it and of course seeing tons of pts. She is vxd obviously but attributes her lack of covid to repeated exposure, like Sub. 82 whose family had covid but was asymptomatic herself. Immunology is fascinating!
So I went back to look at the Discussion, and apparently I mixed up a few of the comments by the researchers. Apparently the asymptomatic case was possibly from the two family members, but the researchers do comment that the results may be the cause of a prior infection.
" However, serum IgG concentrations were constant between ca. 100–200 ng mL−1 (Fig. 7), even preceding the first positive test result, indicating that the unvaccinated participant had acquired some level of immunity from previous, unknown exposure."
So I'll make the proper correction.
But yes, it does highlight the fact that:
1. There appears to be some correlation between severity of illness and humoral response and
2. That even minor exposure that doesn't cause symptoms may produce some form of immunity.
It really does highlight the complexity of these situations. We never know what someone has when we go on with our lives and that may cause us to be exposed to some of the littlest bits of pathogens which don't get us sick but may provide some sort of immunological response.
We've known this to be the case for a long time, but apparently it's one of those things that has been overlooked in the wake of COVID.
Very interesting article- this is the sort of data we ought to have by now. It is a good start and you have raised several great follow-ups to this study.
Overall the data does show a ton of variability between subjects which totally illustrates the complexity of the immune system & the differences between our immune statuses (health of our immune systems at the time of infection). It seems like most things are presented by the powers that be as being black & white, but immunology is nothing but gray!
Yes, by all accounts this is exactly the type of information I would hope for. It's almost as close as we can get to creating individual profiles which can tell us a story.
I'm going to try to post concluding remarks later today, but you've highlighted all of the things I wanted to state. The variability shows us how different we all are. We won't get clear black and white answers because each of us aren't black and white individuals (health-wise, at least!) so to assume that it would be so easy to pinpoint every little nuance would be nearly impossible.
We should always be aware of the fact that we are all different and that means we deal with things differently.
So interesting! My sister-in-law is a primary care dr who has never contracted covid despite her family getting it and of course seeing tons of pts. She is vxd obviously but attributes her lack of covid to repeated exposure, like Sub. 82 whose family had covid but was asymptomatic herself. Immunology is fascinating!
So I went back to look at the Discussion, and apparently I mixed up a few of the comments by the researchers. Apparently the asymptomatic case was possibly from the two family members, but the researchers do comment that the results may be the cause of a prior infection.
" However, serum IgG concentrations were constant between ca. 100–200 ng mL−1 (Fig. 7), even preceding the first positive test result, indicating that the unvaccinated participant had acquired some level of immunity from previous, unknown exposure."
So I'll make the proper correction.
But yes, it does highlight the fact that:
1. There appears to be some correlation between severity of illness and humoral response and
2. That even minor exposure that doesn't cause symptoms may produce some form of immunity.
It really does highlight the complexity of these situations. We never know what someone has when we go on with our lives and that may cause us to be exposed to some of the littlest bits of pathogens which don't get us sick but may provide some sort of immunological response.
We've known this to be the case for a long time, but apparently it's one of those things that has been overlooked in the wake of COVID.