Decade-long careers in research can be made from the seemingly insoluble problem of neurodegeneration, funded as is is by the public and investors to the tune of, surely, a billion of dollars a year or so.
However, prevention, to a large degree, is easy: Ensure everyone has at least the 50 ng/mL (125 nmol/L) circulating 25-hydroxyvitamin D the immune system needs to function properly.
Ayers et al. 2022 https://www.pnas.org/doi/abs/10.1073/pnas.2113489119 showed that Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy (MSA) all involve misfolded (prion) alpha-synuclein tangles and that the structure of the misfolding was different in each of these three conditions.
Ogura et al. 2021, in Japan https://www.sciencedirect.com/science/article/pii/S2405650221000617 showed that MSA sufferers averaged 10.5 ng/mL (26 nmol/L) circulating 25-hydroxyvitamin D and that PD sufferers averaged 13.4 ng/mL (34 nmol/L), while healthy controls averaged 27 ng/mL (67 nmol/L). PD does not lower 25-hydroxyvitamin D https://sci-hub.se/10.1001/archneurol.2011.30, so the causality is from low 25-hydroxyvitamin D to neurodegeneration. (p = 0.0001).
UV-B skin exposure and foods, fortified with vitamin D3 or not, cannot safely and reliably attain the 50 ng/mL level of circulating 25-hydroxyvitamin D (make primarily in the liver from vitamin D3 cholecalciferol, and as measured in "vitamin D" blood tests).
Fortunately, vitamin D3 supplementation in small quantities will attain this 25-hydroxyvitamin D level after several months, with the amount to take, on average, per day, depending on body weight and obesity status, with no need for medical monitoring or 25-hydroxyvitamin D blood tests: New Jersey based Professor of Medicine Sunil Wimalawansa has such recommendations https://vitamindstopscovid.info/00-evi/#00-how-much. These are based on his article: "Rapidly Increasing Serum 25(OH)D Boosts the Immune System, against Infections - Sepsis and COVID-19" Nutrients 2022-07-21 http://www.mdpi.com/2072-6643/14/14/2997 as simplified somewhat in his FLCCC webinar: https://odysee.com/@FrontlineCovid19CriticalCareAlliance:c/Weeekly_Webinar_Aug16_2023:d?t=3386.
0.125 mg (5000 IU) a day on average is sufficient for 70 kg 154 lb body weight without obesity. This is about 8 times greater than what governments and many doctors recommend.
"5000 IUs a day" sounds like a lot, but it is 1/8000th of a gram = 1 gram every 22 years. Pharma grade vitamin D3 costs about USD$2.50 a gram ex-factory. A credit card weighs 5 grams.
Without proper vitamin D3 supplementation such as this, most people - at least in winter - have half or less (down to 1/10th) of the 50 ng/mL 125 nmol/L circulating 25-hydroxyvitamin D they need to be healthy.
Humanity needs about a tonne of vitamin D3 a day for us all to attain at least 50 ng/mL 25-hydroxyvitamin D. At current prices this would be about USD$1 billion a year, but prices would fall with such large scale production.
"In general, it’s scary to think how much of what we know in science may just be built on lies and misinformation": Remember, our scientific creation myth says we came into being out of nothing (ordered by preexisting laws, but never mind that). If that should prove to be wrong, then what else might be wrong? But the model is untestable, so why worry?
Decade-long careers in research can be made from the seemingly insoluble problem of neurodegeneration, funded as is is by the public and investors to the tune of, surely, a billion of dollars a year or so.
However, prevention, to a large degree, is easy: Ensure everyone has at least the 50 ng/mL (125 nmol/L) circulating 25-hydroxyvitamin D the immune system needs to function properly.
Please read the research articles cited and discussed at: https://vitamindstopscovid.info/00-evi/ . Regarding dementia: https://vitamindstopscovid.info/00-evi/#3.3
Ayers et al. 2022 https://www.pnas.org/doi/abs/10.1073/pnas.2113489119 showed that Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy (MSA) all involve misfolded (prion) alpha-synuclein tangles and that the structure of the misfolding was different in each of these three conditions.
Ogura et al. 2021, in Japan https://www.sciencedirect.com/science/article/pii/S2405650221000617 showed that MSA sufferers averaged 10.5 ng/mL (26 nmol/L) circulating 25-hydroxyvitamin D and that PD sufferers averaged 13.4 ng/mL (34 nmol/L), while healthy controls averaged 27 ng/mL (67 nmol/L). PD does not lower 25-hydroxyvitamin D https://sci-hub.se/10.1001/archneurol.2011.30, so the causality is from low 25-hydroxyvitamin D to neurodegeneration. (p = 0.0001).
UV-B skin exposure and foods, fortified with vitamin D3 or not, cannot safely and reliably attain the 50 ng/mL level of circulating 25-hydroxyvitamin D (make primarily in the liver from vitamin D3 cholecalciferol, and as measured in "vitamin D" blood tests).
Fortunately, vitamin D3 supplementation in small quantities will attain this 25-hydroxyvitamin D level after several months, with the amount to take, on average, per day, depending on body weight and obesity status, with no need for medical monitoring or 25-hydroxyvitamin D blood tests: New Jersey based Professor of Medicine Sunil Wimalawansa has such recommendations https://vitamindstopscovid.info/00-evi/#00-how-much. These are based on his article: "Rapidly Increasing Serum 25(OH)D Boosts the Immune System, against Infections - Sepsis and COVID-19" Nutrients 2022-07-21 http://www.mdpi.com/2072-6643/14/14/2997 as simplified somewhat in his FLCCC webinar: https://odysee.com/@FrontlineCovid19CriticalCareAlliance:c/Weeekly_Webinar_Aug16_2023:d?t=3386.
0.125 mg (5000 IU) a day on average is sufficient for 70 kg 154 lb body weight without obesity. This is about 8 times greater than what governments and many doctors recommend.
"5000 IUs a day" sounds like a lot, but it is 1/8000th of a gram = 1 gram every 22 years. Pharma grade vitamin D3 costs about USD$2.50 a gram ex-factory. A credit card weighs 5 grams.
Without proper vitamin D3 supplementation such as this, most people - at least in winter - have half or less (down to 1/10th) of the 50 ng/mL 125 nmol/L circulating 25-hydroxyvitamin D they need to be healthy.
Humanity needs about a tonne of vitamin D3 a day for us all to attain at least 50 ng/mL 25-hydroxyvitamin D. At current prices this would be about USD$1 billion a year, but prices would fall with such large scale production.
New light emitting diodes https://www.houkem.com.cn/high-optical-power-110mw-293nm-295nm-uvb-led-5watt-uv-led-295nm-290nm-293nm-for-vitamin-d.html can probably replace the expensive and inefficient high-pressure mercury vapor lamps https://sci-hub.se/10.1016/B978-0-12-381978-9.10006-X which are used industrially to break a carbon bond in 7-dehydro cholesterol, producing a molecule which isomerizes of its own accord and so becomes vitamin D3 cholecalciferol.
"In general, it’s scary to think how much of what we know in science may just be built on lies and misinformation": Remember, our scientific creation myth says we came into being out of nothing (ordered by preexisting laws, but never mind that). If that should prove to be wrong, then what else might be wrong? But the model is untestable, so why worry?