"More importantly, no comparison to naturally infected individuals was done which just adds more ambiguity."
As well as naive control sera, to rule out nonspecific interactions. This is the same flaw as last year's "poised to acquire" paper (https://www.biorxiv.org/content/10.1101/2021.08.22.457114v1). If a study doesn't have a control, it isn't showing the effect of the intervention - just basic logic, and for some reason all of the ADE and half the imprinting papers flaunt it.
Wow, that's a pretty bold statement from the title alone. It makes sense why it was tweeted to the extent it was and unfortunately I doubt many of those tweets include a proper examination of the study.
I think this study is interesting although it raises a lot of questions as to the actual clinical applications. Like I mentioned the cell lines used here appear to have been designed to overexpress ACEII which raises questions as to the actual relevance for our own myeloid cells. The comparison with the parental cell line, as indicated by the researchers, may suggest an ACEII and FcR dependent mechanism of ADE but now there's quite a good bit of work needing to be done to suggest ADE may occur. It seems that several people missed this part of the study.
What's even stranger is that now people are using this study as some indication that monoclonal antibodies are dangerous and how they were always so weary of them. I wonder if this study will now completely override all of the support for monoclonals without people realizing that most of the monoclonals in use were derived from naturally-infected people and therefore are likely to be the same or similar to the antibodies that we produce in both paratope and functionality.
Thank you Nova! I didn't cover the full breath of the study so if there are any questions such as the vaccinated portion please let me know! There's probably a lot more to talk about in this study!
WHEN is anyone going to finally do a study of injected mice/rats/hamsters/apes/etc. ? It is incredibly bad to do that to them but instead on real billions of people. that's good!!?? It is JUST UNTHINKABLE, how deep the mind programming can get everyone! Since it was NOT done before covid injections, maybe now is the time??? Who is looking into the elastic white clots ??? Another neighbor of mine got clogged neck arteries(!) and waits for the surgery...! His wife died ~5 months after Mod-E-RNA booster of super fast growing cancer, and he is still not getting it, that his problem is also from the same injections he got.. How many more simple people are like that, not grasping the truth? Dying CLUELESS??? ANd sure, all those are NOT COUNTED, NOT IN VAERS SYSTEM!! Instead, hospital like Kaiser Permanente dispose their bodies after a deep investigation to close the Phase III of the studies on people they got to get injected!!! Mengele never died...
On other note, non covid injected people are noticing 'strange' behaviors' of the injected.....
What kind of ‘strange behaviors’? Just curious! I’m not around many injected people these days, honestly, and those that are, stopped at the first two. Not getting boosted.
"More importantly, no comparison to naturally infected individuals was done which just adds more ambiguity."
As well as naive control sera, to rule out nonspecific interactions. This is the same flaw as last year's "poised to acquire" paper (https://www.biorxiv.org/content/10.1101/2021.08.22.457114v1). If a study doesn't have a control, it isn't showing the effect of the intervention - just basic logic, and for some reason all of the ADE and half the imprinting papers flaunt it.
Wow, that's a pretty bold statement from the title alone. It makes sense why it was tweeted to the extent it was and unfortunately I doubt many of those tweets include a proper examination of the study.
I think this study is interesting although it raises a lot of questions as to the actual clinical applications. Like I mentioned the cell lines used here appear to have been designed to overexpress ACEII which raises questions as to the actual relevance for our own myeloid cells. The comparison with the parental cell line, as indicated by the researchers, may suggest an ACEII and FcR dependent mechanism of ADE but now there's quite a good bit of work needing to be done to suggest ADE may occur. It seems that several people missed this part of the study.
What's even stranger is that now people are using this study as some indication that monoclonal antibodies are dangerous and how they were always so weary of them. I wonder if this study will now completely override all of the support for monoclonals without people realizing that most of the monoclonals in use were derived from naturally-infected people and therefore are likely to be the same or similar to the antibodies that we produce in both paratope and functionality.
Wow, thank you for breaking this down in such detail. 👍🏽💕
Thank you Nova! I didn't cover the full breath of the study so if there are any questions such as the vaccinated portion please let me know! There's probably a lot more to talk about in this study!
Wow, what a great piece. I need a number of hours to digest this. Not appropriate after a glass of wine. : )
Thank you Dr. Linda! Please let me know if there are any questions. As a non-wine person I will say that I agree...I think? 🤷♂️
WHEN is anyone going to finally do a study of injected mice/rats/hamsters/apes/etc. ? It is incredibly bad to do that to them but instead on real billions of people. that's good!!?? It is JUST UNTHINKABLE, how deep the mind programming can get everyone! Since it was NOT done before covid injections, maybe now is the time??? Who is looking into the elastic white clots ??? Another neighbor of mine got clogged neck arteries(!) and waits for the surgery...! His wife died ~5 months after Mod-E-RNA booster of super fast growing cancer, and he is still not getting it, that his problem is also from the same injections he got.. How many more simple people are like that, not grasping the truth? Dying CLUELESS??? ANd sure, all those are NOT COUNTED, NOT IN VAERS SYSTEM!! Instead, hospital like Kaiser Permanente dispose their bodies after a deep investigation to close the Phase III of the studies on people they got to get injected!!! Mengele never died...
On other note, non covid injected people are noticing 'strange' behaviors' of the injected.....
What kind of ‘strange behaviors’? Just curious! I’m not around many injected people these days, honestly, and those that are, stopped at the first two. Not getting boosted.
since you read the answer, I'll erase it now. Don't want to generate too much bad feelings among those who unfortunately got the jabs, and regret..