The more I think about it, the more interesting this is -- maybe you should write it up for Medical Hypotheses or some other journal.
This might explain why top-tier athletes are so prone to vaccine injury, especially in aerobic sports. They run high levels of ER stress from exertion (a quick search turned up https://journals.lww.com/acsm-msse/Fulltext/2011/01000/Endoplasmic_Reticulum_Stress_Markers_and.4.aspx). They also generally have high levels of toxins, because they eat very high calorie diets, so will have high intakes of food toxins (polyunsaturated fats, excess retinol and beta-carotene, glyphosate, aluminum, fluoride); all of these toxins increase ER stress.
Feb 24, 2022·edited Feb 25, 2022Liked by Modern Discontent
I went down a similar path in my cancer etiology proposal - that inducing a cell to churn out a protein without destroying it afterward (as a virus does during lysis) will probably result in metabolic disruption. I proposed metaplasia / conversion to secreting phenotypes (https://unglossed.substack.com/p/liquid-cancer) - but stress cascades make sense as well.
Spike is loaded with N, which has a role in folding quality checks via during-translation-glycosylation. I wonder if that would exacerbate or evade ER inflammatory signaling; the latter might make sense since viruses don't like inflammation. I haven't looked into the world of folding from the cell's side yet. ER stress as the etiology for myocarditis sounds like a promising angle. The Zhang citation is great (a lot of really good citations throughout) - though I'm having trouble determining how they are using some of the key phrases at first glance. Language barrier.
If mRNA is transfecting pituitary / pineal cells, then there's your blood-brain barrier bypassed as far as excreted spike. That's been my hunch as far as the neurological effects. This could also account for menstrual disruption (whether via spike or mRNA-metabolic-disruption), and has some really scary implications (rapid aging). *comment edited for typos
Thank you for this different perspective about the vaccines and covid infections. I appreciate it. 👍🏼💜
I have a BS biology and a minor in chemistry, and it would have really helped me to more clearly know what ER stood for (I had to really look for it) and a a short paragraph about that process of ER stress. (From the title I thought you were talking about doctors in the emergency room. 😄).
I will have to re-read a couple more times as the complexities have sometimes overwhelmed my admittedly diminished capabilities to fully grasp the totality of the several ideas presented. That being said, it is a magisterial presentation of a crucial compilation of cellular biology. Thank you!
She also points out the difference between the clinical trial vaccine production where it was high quality and hand-made, vs the stuff they are using now, which is apparently nowhere near as QC'd.
I may have forgot to mention, but unlike sequential exposure to viruses which may acclimate the body to the antigens through immunity, lipid nanoparticles are unlikely to do the same. Considering that constant vaccination supposedly creates greater neutralizing titers, we have to assume that the LNPs are not targeted before they can present mRNA to host cells which then produce the spike protein. Only then, with the presentation of spike protein can an immune response target these spike proteins and cause the body to produce antibodies.
The more I think about it, the more interesting this is -- maybe you should write it up for Medical Hypotheses or some other journal.
This might explain why top-tier athletes are so prone to vaccine injury, especially in aerobic sports. They run high levels of ER stress from exertion (a quick search turned up https://journals.lww.com/acsm-msse/Fulltext/2011/01000/Endoplasmic_Reticulum_Stress_Markers_and.4.aspx). They also generally have high levels of toxins, because they eat very high calorie diets, so will have high intakes of food toxins (polyunsaturated fats, excess retinol and beta-carotene, glyphosate, aluminum, fluoride); all of these toxins increase ER stress.
ER stress can be extremely harmful, for sure. Lyons-Weiler's model is that it causes autoimmunity and can trigger autism. https://ipaknowledge.org/ASD-Causality-Model.php
Full paper at https://ipaknowledge.org/resources/LYONSWEILER%20A1%202019%20b.pptx
I went down a similar path in my cancer etiology proposal - that inducing a cell to churn out a protein without destroying it afterward (as a virus does during lysis) will probably result in metabolic disruption. I proposed metaplasia / conversion to secreting phenotypes (https://unglossed.substack.com/p/liquid-cancer) - but stress cascades make sense as well.
Spike is loaded with N, which has a role in folding quality checks via during-translation-glycosylation. I wonder if that would exacerbate or evade ER inflammatory signaling; the latter might make sense since viruses don't like inflammation. I haven't looked into the world of folding from the cell's side yet. ER stress as the etiology for myocarditis sounds like a promising angle. The Zhang citation is great (a lot of really good citations throughout) - though I'm having trouble determining how they are using some of the key phrases at first glance. Language barrier.
If mRNA is transfecting pituitary / pineal cells, then there's your blood-brain barrier bypassed as far as excreted spike. That's been my hunch as far as the neurological effects. This could also account for menstrual disruption (whether via spike or mRNA-metabolic-disruption), and has some really scary implications (rapid aging). *comment edited for typos
Thank you for this different perspective about the vaccines and covid infections. I appreciate it. 👍🏼💜
I have a BS biology and a minor in chemistry, and it would have really helped me to more clearly know what ER stood for (I had to really look for it) and a a short paragraph about that process of ER stress. (From the title I thought you were talking about doctors in the emergency room. 😄).
Thank you Tim for alerting me to this article. This reference might be of interest - https://www.researchgate.net/publication/327231523_Autism_is_an_Acquired_Cellular_Detoxification_Deficiency_Syndrome_with_Heterogeneous_Genetic_Predisposition
Thank you! I feel so much better, now learning that there may be a reason for my confusion in addition to my slightly addled brain.
I will have to re-read a couple more times as the complexities have sometimes overwhelmed my admittedly diminished capabilities to fully grasp the totality of the several ideas presented. That being said, it is a magisterial presentation of a crucial compilation of cellular biology. Thank you!
Did you see this article?
LNPs and the vaccine in general are discussed: http://enformtk.u-aizu.ac.jp/howard/gcep_dr_vanessa_schmidt_krueger/
She also points out the difference between the clinical trial vaccine production where it was high quality and hand-made, vs the stuff they are using now, which is apparently nowhere near as QC'd.
I may have forgot to mention, but unlike sequential exposure to viruses which may acclimate the body to the antigens through immunity, lipid nanoparticles are unlikely to do the same. Considering that constant vaccination supposedly creates greater neutralizing titers, we have to assume that the LNPs are not targeted before they can present mRNA to host cells which then produce the spike protein. Only then, with the presentation of spike protein can an immune response target these spike proteins and cause the body to produce antibodies.