The Remdesivir Anthology Series Archives

A Collection of posts on Remdesivir and Citations

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This post is comprised of my Remdesivir newsletters where I examined some of the available information surrounding Remdesivir including its possible toxicities.

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Part I: Introduction, Brief History, and Mechanism of Action

This is the first post in the series and sets up the rest of the newsletters down the line. A twitter post lead to a testament by a COVID nurse discussing the ineffectiveness of treatments and the dangers of Remdesivir, leading to the search for evidence of possible toxicity.

Remdesivir: COVID's Standard of Care that May be Causing more Harm than Good (REVIEW)

Part II: The Remdesivir Evidence Before the Pandemic

Remdesivir hasn’t been around for long, but there still exists some in vitro studies of its efficacy. Many of these promising preliminary results lead to its adoption as a possible therapeutic against Ebola. Unfortunately, both the sparse number of studies and questionable results from clinical trials brought Remdesivir’s effectiveness into question.

Remdesivir: COVID's Standard of Care that May be Causing more Harm than Good (REVIEW)

Part III-1: Remdesivir in the Age of COVID

We start to examine the studies of Remdesivir against SARS-COV2 specifically. Once again, in vitro studies showed very promising results. However, the first clinical studies showed inconsistent results, although many factors may attribute to differences in results.

Remdesivir: COVID's Standard of Care that May be Causing more Harm than Good (REVIEW)

Part III-2: Remdesivir in the Age of COVID (Examining the NIH Study)

This post focuses more on the NIH trial (ACCT-1). The interim results of this study was pivotal to Remdesivir’s EUA approval. If we examine the study closely, we will find that the benefits of Remdesivir are highly specific and does not work as a “one size fits all” treatment option.

Remdesivir: COVID's Standard of Care that May be Causing more Harm than Good (REVIEW)

Part IV: Examining the Toxicity & Concluding Remarks

Here we get to the meat of the concern: is Remdesivir actually toxic? The evidence is inconsistent, and although it may not be conclusive, we can at least predict which groups are likely to suffer adverse reactions. I also provide my last remarks on Remdesivir and summarize all of the accumulated evidence.

Remdesivir: COVID's Standard of Care that May be Causing more Harm than Good (REVIEW)

Part V: When you blame everything but the drug.

This is a Paid Subscriber post. Instead of engaging in the precautionary principle and attributing possible toxicity to a drug and all aspects of a drug, it appears that there’s a greater interest in blaming adverse reactions on everything but Remdesivir.

Remdesivir: COVID's Standard of Care that May be Causing more Harm than Good (REVIEW)

Citations:

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2. Slusarczyk, M., Serpi, M. & Pertusati, F. Phosphoramidates and phosphonamidates (ProTides) with antiviral activity. Antiviral chemistry & chemotherapy (2018). Available at: https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5971382/.

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