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The Quercetin Anthology Series

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The Quercetin Anthology Series

A Collection of my Quercetin Newsletters

Modern Discontent
Dec 19, 2021
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The Quercetin Anthology Series

moderndiscontent.substack.com

I’ll be going back in order and collecting my posts together.

Next up is my Quercetin post, which got a lot of traction. Quercetin is one of the most fascinating compounds in the realm of COVID therapeutics and prophylactics. It seems to serve as a jack of all trades compound, and considering that Quercetin is found in many of the fruits and vegetables we consume daily it may point to a long, ancestral relationship between our ancestors and their diet.

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Part I: Brief Overview & Mechanisms of Action

This is a general overview of Quercetin and covers the wide array of Quercetin’s properties, including its antioxidant, antiviral, and immunomodulatory activity. Overall, Quercetin has plenty of benefits.

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Quercetin: An Over-the-Counter Hydroxychloroquine, or Something More?
Since we covered Hydroxychloroquine it seemed appropriate to cover an over-the-counter supplement that has been considered to have the same mechanism of action as HCQ. In this case, the compound in question is called Quercetin. So let’s examine Quercetin and see if this over-the-counter supplement may prove beneficial in helping with COVID…
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a year ago · 7 likes · Modern Discontent

Part II: Targeting SARS-COV2

This newsletter focused solely on Quercetin and its relationship to SARS-COV2 infection. Quercetin may bind to ACEII receptors, which may point to a method of inhibiting viral particles from binding. More specific to the actual virus, Quercetin seems to mainly target the main protease of SARS-COV2 either at the enzyme’s active site or at a site outside of the typical active site.

Modern Discontent
Quercetin: An Over-The-Counter Hydroxychloroquine, or Something More?
Quercetin against SARS-COV2 When it comes to Quercetin acting against SARS-COV2 specifically, we will see some overlaps with Hydroxychloroquine, so know that some things may be reiterated here. I won’t go into more detail about Quercetin as a Zinc Ionophore since there’s isn’t too much evidence, so we’ll dive into other topics…
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a year ago · 8 likes · 4 comments · Modern Discontent

Part III: Clinical Evidence, Perspective, and Concluding Remarks

The literature is a bit scarce when it comes to clinical trials. However, from what I can find and piece together there does seem to be some benefit with prophylactic supplementation and the relationship with COVID infection. More studies will be needed to help add to the literature. With that being said, what we may be seeing instead is not the benefit of actual supplementation but possibly due to a change in the foods we consume and the nutritional content of our typical diets. We may not be seeing improvement due to a compound actually being effective, but because its supplementation is a near return to the diets we all should be eating by adding back in something we are likely to have now depend on. In an era where we continue to become evermore health-conscience we may need to use this as a reevaluation for how we view food and its relationship to our health.

Modern Discontent
Quercetin: An Over-The-Counter Hydroxychloroquine, or Something More?
Clinical Trials Prior to COVID Like all other drugs, most compounds tend to have a spotty record when it comes to effectiveness in human trials. Take this excerpt from Li et. al. 2016(emphasis mine): In a randomized, double-blinded, placebo-controlled trial…
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a year ago · 5 likes · 5 comments · Modern Discontent

Part IV: Citations

I will try to post citations together with these collections to save up room. But since this was already posted separately here ya go!

Modern Discontent
Quercetin: An Over-The-Counter Hydroxychloroquine, or Something More?
Although all of the studies I used are linked throughout the newsletters, here’s a collection for anyone who wants to look at the studies themselves. It’s important to note that I may have misinterpreted a study or missed important information, so for those who are interested in fact checking and examining the studies themselves you can do so…
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a year ago · 3 likes · Modern Discontent

Note: I have decided to put pictures of random books to signify the Anthology posts to try to differentiate them from the other posts (I don’t see me posting random books for other reasons) but if you prefer to have the cover photo be related to the actual content please let me know. I would prefer to use the method most people will find appropriate.

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The Quercetin Anthology Series

moderndiscontent.substack.com
10 Comments
Nova123
Dec 19, 2021Liked by Modern Discontent

Thank you, this is really helpful for giving information to others. I don't have to go back and find a bunch of links and give them in the order that is best understood. 🙏👍🏼

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Deborah Peterson
Dec 29, 2021Liked by Modern Discontent

Is printing of the articles available with the paid subscription? It is easier for me to read printed materials than to read them on a screen. Thank you.

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