Modern Discontent

Share this post
The Nasal Passage Anthology Series Archives
moderndiscontent.substack.com
The Anthology Series Archives

The Nasal Passage Anthology Series Archives

A series of newsletters looking into the nasal passage.

Modern Discontent
Dec 29, 2021
3
Share this post
The Nasal Passage Anthology Series Archives
moderndiscontent.substack.com

This post was copied and pasted over from Modern Discontent. If you are interested in Anthology Series posts as they come in or are interested in smaller posts along the way please consider subscribing over there as that is the main Substack. Also, paid-only content will only be available through becoming a paid member on Modern Discontent.

This post was made several months ago and the information may be out of date. Please keep that in mind when reading through this series.


This was one of my first series of posts. COVID infection tends to begin first within the nasal passage. A majority of people infected with COVID also present with anosmia as well so it seemed fitting to look at the information and see what role the nasal passage plays in infection.

Do note that many of this information is likely to be outdated at this point. For example, some recent evidence has come out suggesting that anosmia may not be caused by damage to the olfactory bulb and may be due to the damaging of peripheral cells that the olfactory bulb depends on.

Out of all of my posts I will likely update this one soon with more recent literature.

Part I: Infection, Neuroinvasion, and Children

This is likely to be the most outdated of the posts. However, the information here is still pertinent. I indicate how SARS-COV2 infection occurs and the likely pathway for neuroinvasion. I also indicate some evidence as to why children tend to fare better with COVID which may be due to a robust innate immune system in children as well as lower ACEII expression.

Modern Discontent
A Pathogen's Guide to the Nose (Review)
The nose is a magical structure. It provides us the ability to smell all manners of sweet goodness, whether it is the scent of desiccating leaves on an Autumn day, the smell of fresh baked goods pulled right from the oven, or even the smell of our favorite scented candles. But it also allows us to smell putrid things that may be harmful to us such as ro…
Read more
8 months ago · 3 likes · Modern Discontent

Part II: Therapeutics, Prophylaxis, and Vaccination

Because the nasal passage serves as the initial site of infection it makes sense that therapeutics that target this site may be needed. Here, I explain a few of the therapeutics and prophylaxis being examined at the time. I also include information on an intranasal vaccine and why there may be some concerns with there.

This is a Paid Subscribers’ post, although I have retroactively added a small preview for those who are interested in seeing what is in this piece.

Modern Discontent
A Pathogen's Guide to the Nose (Review)
I previously indicated the vital role the nasal route plays in virus infection and how this could lead to the manifestation of anosmia and possibly other neurocognitive impairments. It would make sense then to argue that interventions administered intranasally may provide the best route of protection and treatment for the early stages of COVID, and that prophylactic measures may want to look in this direction if we want the best, full frontal response against the virus…
Read more
8 months ago · 1 like · 5 comments · Modern Discontent

Part III: At Home Nasal Remedies & The Coming Winter

Part II focused on many forms of prescription therapeutics. However, this one focused on many things that people can find available over the counter or online. In a time of winter people may be looking to find things that they can do to help and protect themselves. Remember that these newsletters are intended to be informative and not prescriptive. Use these as a starting point to find information and make your own informed decisions.

Modern Discontent
A Pathogen's Guide to the Nose (Review)
At Home Nasal Interventions In my paid only Substack post I posted about therapeutics and prophylactics that could be administered intranasally. However, I ran out of space in that post (apparently 10 pages worth is the limit!) and so I have taken portions of that post and am posting it here, which works out since many of these may be more applicable to …
Read more
8 months ago · 9 comments · Modern Discontent

Citations

Here are the sources for Part I and Part III, respectively. Apparently Substack allows posts up to the limit that can be sent through an email. I learned that the hard way, and so my citations were placed into a separate post.

Modern Discontent
A Pathogen's Guide to the Nose (Citations)
So I posted a newsletter a few hours ago about the nasal passage. I did not realize, but apparently there is a size limit on Substack posts, well, at least a limit on what can be sent via email. Because of that I’m posting my citations here. If you have any issues with seeing a newsletter via email please let me know…
Read more
8 months ago · Modern Discontent
Modern Discontent
A Pathogen's Guide to the Nose (Part III Citations)
Okay, one more separate citation post! Well… we’ll see. Anyways if you are having trouble opening the main review paper due to the size please let me know and I’ll chop it up. In-Text Citation Kontos, Z. 2021. Efficacy of “Essential Iodine Drops” against Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2…
Read more
8 months ago · Modern Discontent

Hopefully this information can help inform you about how to approach COVID with the winter season!

Thank you for reading Modern Discontent. This post is public so feel free to share it.

Share

Modern Discontent is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

Share this post
The Nasal Passage Anthology Series Archives
moderndiscontent.substack.com
Comments

Create your profile

0 subscriptions will be displayed on your profile (edit)

Skip for now

Only paid subscribers can comment on this post

Already a paid subscriber? Sign in

Check your email

For your security, we need to re-authenticate you.

Click the link we sent to , or click here to sign in.

TopNewCommunity

No posts

Ready for more?

© 2022 Modern Discontent
Privacy ∙ Terms ∙ Collection notice
Publish on Substack Get the app
Substack is the home for great writing