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The Fluvoxamine Anthology Series Archives
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The Anthology Series Archives

The Fluvoxamine Anthology Series Archives

A Collection of Fluvoxamine Posts including the "Pseudoinfection" Hypothesis & Citations

Modern Discontent
Feb 25
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This post was copied and pasted over from Modern Discontent. If you are interested in Anthology Series posts as they come in or are interested in smaller posts along the way please consider subscribing over there as that is the main Substack. Also, paid-only content will only be available through becoming a paid member on Modern Discontent.


I hope you’re all not exhausted from all of the posts! Fluvoxamine has fallen into infamous category of repurposed COVID drugs that may never see common use. It’s an SSRI that has been in use for several decades for the treatment of depression as well as other neurocognitive impairments. Overall, it’s an inexpensive drug with a broad spectrum of activity and decades of safety, to the extent that it may be even fruitful to examine it for both long COVID and for those suffering from vaccine adverse reactions.

I’ll end this entire series with one more additional post that helps to summarize a few of the key points with Fluvoxamine (Wu et. al.):

One thing to point out is Point 2. Like with most clinical trials participants under 18 and pregnant women are excluded. However, because Fluvoxamine has been prescribed for decades there should be well established evidence of its safety in children. Yes, Fluvoxamine is prescribed to children, and even pregnant women. If someone chooses to discuss Fluvoxamine with medical professionals, care should be taken to look at Point 4 and discuss possible contraindications with medications already in use.

So with that I’ll collect all of the prior Fluvoxamine posts and will include citations below. Note that my citations focus solely on science articles and papers. If readers prefer I include all of the articles I link to please let me know.

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Fluvoxamine- The Little SSRI that Could

Part I: Brief Overview, Tortuous History, and MOAs

Like with all posts the first part introduces Fluvoxamine, providing a brief history into it’s structure and development. I also briefly discuss the emerging concerns over SSRIs through the context of Fluvoxamine’s relationship to the Columbine Shooting Massacre. Lastly, I discuss some of Fluvoxamine’s mechanisms of action.

Modern Discontent
Fluvoxamine: The Little SSRI that Could – Part I
Note: This post has surpassed the email limit and may be truncated to fit the maximum email size. If so, please continue reading this post on the Substack page. Over the past two years, the validation of a viable COVID therapeutic was always based off of the mantra of…
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3 months ago · 10 likes · 6 comments · Modern Discontent

Part II: Nonclinical Examination of Lysosomotropism and the ASM/Ceramide Pathway

Going more in depth I then examine each MOA in further detail. Based on my research I found it important to discuss Lysosomotropism and the ASM/Ceramide pathway, although I decided to skip over discussing some of these MOAs in Part I, and therefore included it here. I then provide studies from the literature involving these pathways, and include studies involving these pathways, Fluvoxamine (or Fluoxetine) and SARS-COV2 infection.

Modern Discontent
Fluvoxamine- The Little SSRI That Could: Part II
This post has gone over the email limit and may become truncated. If so, please check for the full post at the Substack Page. Just a bit More Information So, I said that I would truncate the information in the prior post, but there’s just a few more things to add that are important for evaluating the nonclinical studies in this post. This will mostly incl…
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3 months ago · 7 likes · Modern Discontent

Part III: Nonclinical Examination of Fluvoxamine, Sigma-1 Agonism and ER Stress

Just like Part II this post goes deeper into the last MOA being examined. It’s probably one of the most important due to the role ER Stress plays in many diseases including diabetes, cardiovascular disease, and neurodegeneration just to name a few. Although there’s no studies providing a causal link between Fluvoxamine, S1R receptors, ER Stress, and SARS-COV2 infection the information provided allows for as close of an examination as possible.

Modern Discontent
Fluvoxamine- The Little SSRI That Could: Part III
A Little More on Sigma-1, ER Stress, and COVID Note: Brace yourselves for another long post! Hopefully it will be the last in this series. If you are unable to view the entire post please check the main hub. Also, please let me know if you feel this information is too dense or too long. I would love to get some feedback…
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3 months ago · 7 likes · 11 comments · Modern Discontent

Part IV: Nonclinical Examination of Fluoxetine/Fluvoxamine & Emerging Clinical Trial Results

Finally, we take a look at clinical trials involving Fluvoxamine, including the well-known TOGETHER trial. Beforehand, I provide two more in vitro assays suggesting that both Fluvoxamine and Fluoxetine are effective in reducing SARS-COV2 infection. Overall, the results all suggest that Fluvoxamine should be an effective therapeutic agent for fighting COVID.

Modern Discontent
Fluvoxamine- The Little SSRI that Could: Part IV
With Mechanisms of Actions out of the way, we can now focus on Clinical Trials. However, I’ll first start with two more in vitro studies; one that examined Fluoxetine and another that examined Fluvoxamine against SARS-COV2 infection. I will go through these briefly and focus mostly on the pertinent results…
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3 months ago · 4 likes · 3 comments · Modern Discontent

A Proposed "Pseudo-infection" Hypothesis

Research into Fluvoxamine led me to think about parallels between the vaccines and COVID infection. Although the original hypothesis wanted to examine the vaccines through their role in inducing ER Stress, I changed my hypothesis to examine the vaccination process through the lens of a “pseudoinfection”, addressing the importance of examining all aspects of the vaccines in order to gain a better understanding about these adverse reactions.

Modern Discontent
A Possible Relationship between ER Stress, COVID Infection, and Vaccine Adverse Reactions
Note: This post is not exhaustive, and is intended to be informative and present a possible hypothesis. The information here should not be used as medical advice and is intended to inform and provide perspective to the scenario presented below. When I first started looking into Fluvoxamine the first papers I came across were ones discussing its Sigma-1 a…
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3 months ago · 13 likes · 26 comments · Modern Discontent

Note: The Citations will make this post too long and so I will post it separately and link it here. Apologies for the inconvenience!

Link to Citations


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Citations

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  2. Marčec, R., & Likić, R. (2021). Could fluvoxamine keep COVID-19 patients out of hospitals and intensive care units?. Croatian medical journal, 62(1), 95–100. https://doi.org/10.3325/cmj.2021.62.95

  3. Lenze, E. J., Mattar, C., Zorumski, C. F., Stevens, A., Schweiger, J., Nicol, G. E., Miller, J. P., Yang, L., Yingling, M., Avidan, M. S., & Reiersen, A. M. (2020). Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical Trial. JAMA, 324(22), 2292–2300. https://doi.org/10.1001/jama.2020.22760

  4. Rosen, D. A., Seki, S. M., Fernández-Castañeda, A., Beiter, R. M., Eccles, J. D., Woodfolk, J. A., & Gaultier, A. (2019). Modulation of the sigma-1 receptor-IRE1 pathway is beneficial in preclinical models of inflammation and sepsis. Science translational medicine, 11(478), eaau5266. https://doi.org/10.1126/scitranslmed.aau5266

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Dianne
Feb 25Liked by Modern Discontent

Thank you for your thorough report on Fluvoxamine and for putting all your posts into a single experience so they can be more easily accessed. Your work and wonderful explanations are deeply appreciate.

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