These will be my answers to the questions I raised at the end of my Introduction to Pharmacology Post from last week.
For those who haven’t seen it the Applied Knowledge Questions were the following (I also suggest people read that post before attempting some of the questions):
If these questions were too confusing or vague, think about drugs from the concept of pharmacodynamics1 and pharmacokinetics specifically.
With pharmacodynamics, think of which enzymes or receptors may be targeted by a drug.
With pharmacokinetics, think of the acronym LADME and see how many of those letters you can answer.
Overall, remember that the intent when answering these questions is not to answer in full, but to answer with the best of your knowledge or what you can source. If the drug targets a completely unknown enzyme pathway, it’s acceptable to not know anything about that pathway- remember that a drug’s effects should tell you something about the pathway it is targeting.
Also, keep in mind that these exercises are intended to be a learning process and serves as the building blocks for greater information down the line. If you become curious about different cellular or enzymatic pathways, use this to start the journey for further learning.
The drugs taken into consideration are below, however there is a major correction to make. As far as I am aware, there are no ACEII inhibitors. Hypertension medications either target ACE or the Angiotensin II Receptor and NOT ACEII receptors (Angiotensin converting enzyme II). Apologies for the mix up- it’s a very egregious mistake to make- and the pharmacology post was corrected accordingly.
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