Long COVID Anthology Series Archives

A Collection of the Long COVID Posts & Citations

This post was copied and pasted over from Modern Discontent. If you are interested in Anthology Series posts as they come in or are interested in smaller posts along the way please consider subscribing over there as that is the main Substack. Also, paid-only content will only be available through becoming a paid member on Modern Discontent.

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Preface

So stupid me just figured out that I can just Update my prior anthology posts and just link it to the new Anthology Section rather than copying and pasting them. Apologies for those who had to suffer through the bombardment of all of those recent anthology posts as I tried to figure out how to transfer them over. I am not a millennial in any form in regards to tech and there’s still plenty of features of Substack that I am still figuring out.

For newcomers who may be interested in those anthology series please check The Anthology Series Archives header for all of the prior posts. Some of the information there may be outdated but I think many of them still hold up fairly well.

The Lingering Unknowns of Long COVID

Just as the pandemic’s apex is coming to a close we are still left to wonder about the origins of COVID and why no proper treatments for COVID have been widely available. This mystery of the unknown pervades much of Long COVID even today. Whether Long COVID is as prevalent as we believe, if COVID may be the direct link to many of the symptoms of Long COVID, or if the entire lockdown and isolation process has left millions with lingering feelings of stress, anxiety, and depression that have manifested over the past few years we have been under COVID.

Many people continue to have questions in regards to the extent of COVID damage after an infection. Although the information provided here in no ways encapsulates all of the information surrounding Long COVID, it does provide a window into Long COVID as an idea and what we can do about it.

PART I:Long COVID Introduction, the Namesake, and a History of Post-Viral Syndrome

The first post in the Long COVID series covered a few different topics. It provided a blueprint for what defines Long COVID. It also explains where the name and some of the other terms using have come from. Lastly, I indicate that COVID is not the only virus to cause lingering symptoms much after an infection, and that there is even a term- Post-Viral Syndrome- that is part of the vernacular in medical literature, which would suggest that viruses have had a longstanding history of causing long-term damage to the body.

The Complications of “Long Covid” Part I

PART II: Risk Factors and General Symptoms

The medical community is still figuring out who is at greater risk of developing Long COVID. Unfortunately, most of the information right now is either speculative or correlative. Unsurprisingly, factors that make people more susceptible to COVID itself are more likely to experience Long COVID as well. The symptoms of Long COVID are just as diverse as COVID itself with symptoms arising from many different organ systems. However, the most important aspect of Long COVID is what symptoms are tied to what organ systems.

The Complications of “Long COVID” Part II

PART III: Causes of Long COVID

The causes for the symptoms people are experiencing are still not fully pinned down. Once again, the causes are likely linked to where the damage from COVID has occurred. Although many of the ideas from the following post are hypothetical, many recent findings have validated some of the hypotheses listed.

The Complications of "Long COVID" Part III

PART IV: Post-Vaccine Syndrome and Management and Treatment of Long COVID

Many of the systems experienced post-vaccine have mimicked those of either the virus itself or Long COVID. Why such similarities are occurring have still not been answered, but their mere existence is concerning on its own. It’s strange how heavily emphasized Long COVID is yet the adverse reactions many people are experiencing post-vaccine are being severely downplayed.

There has been conclusive treatment option for those experiencing both Long COVID and Post-Vaccine Syndrome. Nonetheless, many options may still be tried, with a heavy emphasis on behavioral or lifestyle modifications to correct for all of the maladies caused by extensive lockdowns and isolations. Many herbal remedies or supplements may provide some benefit as well, although the jury is still out on many of these treatment routes. Regardless, always make sure to do some research and seek out medical professionals who you trust will engage in open dialogue and provide an unbiased, nuanced opinion.

The Complications of “Long COVID” Part IV

Paid Post: Hair Loss, Impotence, and COVID

COVID can present with many different symptoms and side effects. However, we tend to not consider the more sensitive topics. Many people may not want to discuss things such as erectile dysfunction with many people, but the realities of COVID make these discussions important. This paid subscriber-only post dives into the evidence of both hair loss and erectile dysfunction from a COVID infection, whether this is a widespread phenomenon, is this something not out of the ordinary or are there important things we should look out for?

Hair Loss, Impotence, and COVID

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Citations

1. Raveendran, A. V., Jayadevan, R., & Sashidharan, S. (2021). Long COVID: An overview. Diabetes & metabolic syndrome, 15(3), 869–875. https://doi.org/10.1016/j.dsx.2021.04.007

2. Callard, F., & Perego, E. (2021). How and why patients made Long Covid. Social science & medicine (1982), 268, 113426. https://doi.org/10.1016/j.socscimed.2020.113426

3. Bannister B. A. (1988). Post-infectious disease syndrome. Postgraduate medical journal, 64(753), 559–567. https://doi.org/10.1136/pgmj.64.753.559

4. Archer M. I. (1987). The post-viral syndrome: a review. The Journal of the Royal College of General Practitioners, 37(298), 212–214.

5. Murdoch J. C. (1987). Post-viral syndrome. The Journal of the Royal College of General Practitioners, 37(304), 512.

6. Garg, M., Maralakunte, M., Garg, S., Dhooria, S., Sehgal, I., Bhalla, A. S., Vijayvergiya, R., Grover, S., Bhatia, V., Jagia, P., Bhalla, A., Suri, V., Goyal, M., Agarwal, R., Puri, G. D., & Sandhu, M. S. (2021). The Conundrum of 'Long-COVID-19': A Narrative Review. International journal of general medicine, 14, 2491–2506. https://doi.org/10.2147/IJGM.S316708

7. Jimeno-Almazán, A., Pallarés, J. G., Buendía-Romero, Á., Martínez-Cava, A., Franco-López, F., Sánchez-Alcaraz Martínez, B. J., Bernal-Morel, E., & Courel-Ibáñez, J. (2021). Post-COVID-19 Syndrome and the Potential Benefits of Exercise. International journal of environmental research and public health, 18(10), 5329. https://doi.org/10.3390/ijerph18105329

8. Ladds, E., Rushforth, A., Wieringa, S., Taylor, S., Rayner, C., Husain, L., & Greenhalgh, T. (2020). Persistent symptoms after Covid-19: qualitative study of 114 "long Covid" patients and draft quality principles for services. BMC health services research, 20(1), 1144. https://doi.org/10.1186/s12913-020-06001-y

9. Yong S. J. (2021). Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments. Infectious diseases (London, England), 53(10), 737–754. https://doi.org/10.1080/23744235.2021.1924397

10. Patterson, B. K., Guevara-Coto, J., Yogendra, R., Francisco, E. B., Long, E., Pise, A., Rodrigues, H., Parikh, P., Mora, J., & Mora-Rodríguez, R. A. (2021). Immune-Based Prediction of COVID-19 Severity and Chronicity Decoded Using Machine Learning. Frontiers in immunology, 12, 700782. https://doi.org/10.3389/fimmu.2021.700782

11. Oronsky, B., Larson, C., Hammond, T. C., Oronsky, A., Kesari, S., Lybeck, M., & Reid, T. R. (2021). A Review of Persistent Post-COVID Syndrome (PPCS). Clinical reviews in allergy & immunology, 1–9. Advance online publication. https://doi.org/10.1007/s12016-021-08848-3

12. Algaadi S. A. (2021). Herpes zoster and COVID-19 infection: a coincidence or a causal relationship?. Infection, 1–5. Advance online publication. https://doi.org/10.1007/s15010-021-01714-6

13. Anne Louise Oaklander, Alexander J. Mills, Mary Kelley, Lisa S. Toran, Bryan Smith, Marinos C. & Dalakas, Avindra. Peripheral Neuropathy Evaluations of Patients With Prolonged Long COVID. Nath Neurol Neuroimmunol Neuroinflamm May 2022, 9 (3) e1146; DOI: 10.1212/NXI.0000000000001146

14. Song, W. J., Hui, C., Hull, J. H., Birring, S. S., McGarvey, L., Mazzone, S. B., & Chung, K. F. (2021). Confronting COVID-19-associated cough and the post-COVID syndrome: role of viral neurotropism, neuroinflammation, and neuroimmune responses. The Lancet. Respiratory medicine, 9(5), 533–544. https://doi.org/10.1016/S2213-2600(21)00125-9

15. Sher L. (2021). Post-COVID syndrome and suicide risk. QJM : monthly journal of the Association of Physicians, 114(2), 95–98. https://doi.org/10.1093/qjmed/hcab007

16. Petrovszki, D., Walter, F. R., Vigh, J. P., Kocsis, A., Valkai, S., Deli, M. A., & Dér, A. (2022). Penetration of the SARS-CoV-2 Spike Protein across the Blood-Brain Barrier, as Revealed by a Combination of a Human Cell Culture Model System and Optical Biosensing. Biomedicines, 10(1), 188. https://doi.org/10.3390/biomedicines10010188

17. Alan C-Y. Hsu, Guoqiang Wang, Andrew T. Reid, Punnam Chander Veerati, Prabuddha S. Pathinayake, Katie Daly, Jemma R. Mayall, Philip M. Hansbro, Jay C. Horvat, Fang Wang, Peter A. Wark. SARS-CoV-2 Spike protein promotes hyper-inflammatory response that can be ameliorated by Spike-antagonistic peptide and FDA-approved ER stress and MAP kinase inhibitors in vitro bioRxiv 2020.09.30.317818; doi: https://doi.org/10.1101/2020.09.30.317818

18. Echavarría-Consuegra, L., Cook, G. M., Busnadiego, I., Lefèvre, C., Keep, S., Brown, K., Doyle, N., Dowgier, G., Franaszek, K., Moore, N. A., Siddell, S. G., Bickerton, E., Hale, B. G., Firth, A. E., Brierley, I., & Irigoyen, N. (2021). Manipulation of the unfolded protein response: A pharmacological strategy against coronavirus infection. PLoS pathogens, 17(6), e1009644. https://doi.org/10.1371/journal.ppat.1009644